3-(4-Chloro-2-methylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole

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Names

[ CAS No. ]:
75318-76-2

[ Name ]:
3-(4-Chloro-2-methylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole

Chemical & Physical Properties

[ Density]:
1.264g/cm3

[ Boiling Point ]:
513.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄ClN₃O

[ Molecular Weight ]:
299.75500

[ Flash Point ]:
264.5ºC

[ Exact Mass ]:
299.08300

[ PSA ]:
50.80000

[ LogP ]:
4.10910

[ Index of Refraction ]:
1.612

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ4504000

CHEMICAL NAME :: s-Triazole, 3-(4-chloro-o-tolyl)-5-(m-methoxyphenyl)-

CAS REGISTRY NUMBER :: 75318-76-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H14-Cl-N3-O

MOLECULAR WEIGHT :: 299.78

WISWESSER LINE NOTATION :: T5MN DNJ CR DG B1& ER CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2500 ug/kg

SEX/DURATION :: female 6-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1187,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 25 mg/kg

SEX/DURATION :: female 4-8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1187,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 ug/kg

SEX/DURATION :: female 4-8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1187,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 ug/kg

SEX/DURATION :: female 4-8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK) V.3- 1980- Volume(issue)/page/year: 4,237,1982

Synthetic Route

Click to get detail synthetic route

Related Compounds

3-[4-(Difluoromethyl)-1,3-thiazol-2-yl]-4-methoxybenzoic acid
(R)-2-(3-Fluorocyclobutyl)propan-1-amine
(2R)-3-[4-(Difluoromethyl)phenyl]-2-methylpropan-1-amine
Tert-butyl 6-(trifluoromethyl)piperidine-2-carboxylate
6-Fluoro-2-methyl-3-(phenylmethoxycarbonylamino)benzoic acid
3-Chloro-2-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-carboxylic acid
4-Methoxy-1,2-dihydrospiro[indole-3,4'-piperidine]-2-one dihydrochloride
2,3-Dihydropyrazolo[5,1-b]oxazol-7-amine 2,2,2-trifluoroacetate
(2-Cyclopropylpyridin-3-yl)methanamine dihydrochloride
2,7,10-Triazaspiro[5.6]dodecan-11-one dihydrochloride

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