Moxonidine

Suppliers

Names

[ Name ]:
Moxonidine

[Synonym ]:
4-chloro-5-(imidazoline-2-ylamino)-6-methoxy-2-methylpyrimidine
[3H]-Moxonidine
4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine
4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine
Norcynt
4-Chloro-N-(imidazolidin-2-ylidene)-6-methoxy-2-methylpyrimidin-5-amine
BE 5895
5-Pyrimidinamine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-
Normoxocin
Lomox
4-chloro-N-(4,5-dihydro-1H9imidazol-yl)-6-methoxy-2-methyl-5-pyrimidinamine
Physiotens
[14C]-Moxonidine
4-chloro-5-[(4,5-dihydro-1H-imidazol-2-yl)-amino]-6-methoxy-2-methylpyrimidine
T6N CNJ B1 DO1 FG EM- BT5M CN BUTJ
Nucynt
Cynt
Moxonidinum [Latin]
Moxonidine
T6N CNJ B1 DO1 FG ENU- BT5MYMTJ
MFCD06795643

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
364.7±52.0 °C at 760 mmHg

[ Melting Point ]:
40-43 °C(lit.)

[ Molecular Formula ]:
C₉H₁₂ClN₅O

[ Molecular Weight ]:
241.678

[ Flash Point ]:
174.3±30.7 °C

[ Exact Mass ]:
241.073044

[ PSA ]:
71.43000

[ LogP ]:
0.84

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.681

[ Storage condition ]:
Desiccate at +4°C

Safety Information

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UV6260290

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyridine
Methanol
mono-Moxonidine oxalate
Sodium Methylate
1-[1-((4,6-dichloro-2-methyl-pyrimidin-5-yl)imino)-ethyl]-imidazolidin-2-one

DownStream

Articles

Selective imidazoline agonist moxonidine plus the ACE inhibitor ramipril in hypertensive patients with impaired insulin sensitivity: partners in a successful MARRIAGE?

Curr. Med. Res. Opin. 20(3) , 359-67, (2004)

Hypertension in combination with clinically overt diabetes mellitus is recognized as a particularly powerful combination of risk factors that greatly increases cardiovascular vulnerability. There is a...

Moxonidine: a review of safety and tolerability after seven years of clinical experience.

J. Hypertens. 17 , S37-S39, (1999)

Centrally acting antihypertensive drugs, or sympatholytics, (reserpine, methyldopa and clonidine) have a long history of efficacy but are now little used in most countries. One of the most important r...

[The efficacy of antihypertension drugs and their combinations in the non-treated hypertension].

Med. Tr. Prom. Ekol. (5) , 7-11, (2013)

In case of non-treated hypertension several medications and their combinations were studied (captopril, and moxonidine as such, captopril + nifedipine, captopril + moxonidine). Moxonidine to be more e...

Moxonidine-d4
Moxonidine HCl
Moxonidine HCl
4-Methoxy Moxonidine
Dihydroxy Moxonidine
mono-Moxonidine oxalate
2-Chloro-d-phenylalanine methyl ester hcl
Tert-butyl 2-ethynyl-5,5-dimethylmorpholine-4-carboxylate
4-Fluoro-3-[2-(1-methyl-4-piperidinyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenamine
Methyl 3-[2-(2-amino-4-bromo-5-chloro-3-pyridinyl)ethynyl]-1-piperidinecarboxylate
4-(4-fluoro-2-methoxyphenyl)-2-pyrrolidin-3-yl-1H-pyrrolo[2,3-b]pyridine
3-((4,5-Dimethyl-6-oxopyrimidin-1(6H)-yl)methyl)benzoic acid
1,1-Dimethylethyl 3-(4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-1-azetidinecarboxylate
N-Benzyl-6-bromopyrazin-2-amine
3-methoxy-4-(2-(piperidin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)benzonitrile
N4-(4-chlorobenzyl)-6-(3-(methylamino)azetidin-1-yl)pyrimidine-2,4-diamine

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