Butantrone

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Names

[ CAS No. ]:
75464-11-8

[ Name ]:
Butantrone

[Synonym ]:
10-butyryl-1,8-dihydroxy-9-anthron
Butantrona [Spanish]
Butantronum [Latin]
Dithranol,10-butyryl
1,8-dihydroxy-10-(1'-oxobutyl)-9(10H)-anthracenone
9(10H)-ANTHRACENONE,1,8-DIHYDROXY-10-(1-OXOBUTYL)
Butantrona
1,8-dihydroxy-10-butyrylanthrone
10-Butyryl dithranol
10-butyryl-1,8-dihydroxy-9(10H)-anthracenone
Butantrone

Chemical & Physical Properties

[ Density]:
1.324g/cm3

[ Boiling Point ]:
490.1ºC at 760 mmHg

[ Molecular Formula ]:
C18H16O4

[ Molecular Weight ]:
296.31700

[ Flash Point ]:
264.3ºC

[ Exact Mass ]:
296.10500

[ PSA ]:
74.60000

[ LogP ]:
3.14330

[ Index of Refraction ]:
1.641

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB1500000
CHEMICAL NAME :
9(10H)-Anthracenone, 1,8-dihydroxy-10-(1-oxobutyl)-
CAS REGISTRY NUMBER :
75464-11-8
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C18-H16-O4
MOLECULAR WEIGHT :
296.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1579 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
139 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 59,180,1986

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Dithranol
  • Butyryl chloride

DownStream

  • Dantron

Related Compounds

  • Butantrone
  • 2-[(6-chloro-3,4-dimethyl-2-oxo-2H-chromen-7-yl)oxy]-N-(1H-indol-4-yl)acetamide
  • methyl 2-{[3-(4-hydroxy-6-methyl-2-oxopyridin-1(2H)-yl)propanoyl]amino}-5-phenyl-1,3-thiazole-4-carboxylate
  • N-cyano-3-ethyl-N-{[5-(3-fluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}aniline
  • 4-chloro-3-(1,1-dioxido-1,2-thiazinan-2-yl)-N-([1,2,4]triazolo[4,3-a]pyridin-3-ylmethyl)benzamide
  • 2-(3-isopropyl-4-oxo-3,4-dihydro-1-phthalazinyl)-N-(2-[1,2,4]triazolo[4,3-a]pyridin-3-ylethyl)acetamide
  • 3-(5-methyl-1H-tetrazol-1-yl)-N-[1-(propan-2-yl)-1H-indol-4-yl]benzamide
  • 1-(2-Azidoethyl)-7-methoxynaphthalene
  • 1-(4-Benzylpiperazino)-4-(6-methoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)-1-butanone
  • 2-(2-methoxyethyl)-1-oxo-N-(4H-1,2,4-triazol-3-yl)-1,2-dihydroisoquinoline-4-carboxamide
  • N-[2-(3,4-dimethoxyphenyl)ethyl]-5-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]methyl}furan-2-carboxamide
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