Regorafenib (BAY 73-4506)

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Names

[ CAS No. ]:
755037-03-7

[ Name ]:
Regorafenib (BAY 73-4506)

[Synonym ]:
BAY734506
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino] carbonyl]amino]-3-fluorophenoxy]-N-methyl-
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
Regorafenib
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
Stivarga
BAY73-4506
4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
BAY 73-4506

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
513.4±50.0 °C at 760 mmHg

[ Melting Point ]:
206.0 to 210.0 °C

[ Molecular Formula ]:
C21H15ClF4N4O3

[ Molecular Weight ]:
482.815

[ Flash Point ]:
264.3±30.1 °C

[ Exact Mass ]:
482.076874

[ PSA ]:
92.35000

[ LogP ]:
5.26

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.616

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
29242990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide
  • 4-Chloro-3-(trifluoromethyl)phenylisocyanate
  • 3-Fluoro-4-nitrophenol
  • 4-Amino-3-fluorophenol

DownStream

  • Regorafenib (Hydrochloride)

Related Compounds

  • Regorafenib Monohydrate
  • (S)-BAY73-6691
  • Niclosamide olamine
  • BAY 73-6691 racemate
  • BAY 73-1449
  • BAY 73-6691
  • 1-(2-Methoxybenzoyl)-4-(thiolan-3-yl)-1,4-diazepane
  • (3-Methoxyphenyl)(4-(tetrahydrothiophen-3-yl)-1,4-diazepan-1-yl)methanone
  • N-isopropylpyrido[3,4-d]pyrimidin-4-amine
  • N,2,2-trimethyl-N-(1-{[1,2,4]triazolo[4,3-b]pyridazin-6-yl}azetidin-3-yl)cyclopropane-1-carboxamide
  • N-methyl-N-(1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)azetidin-3-yl)isobutyramide
  • 2-(2-Chloro-6-fluorophenyl)-1-(4-(tetrahydrofuran-3-yl)-1,4-diazepan-1-yl)ethan-1-one
  • N-(1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)azetidin-3-yl)-N-methylisobutyramide
  • 1-(4-(((5,6-Dimethylpyrimidin-4-yl)oxy)methyl)piperidin-1-yl)-4,4,4-trifluorobutan-1-one
  • 4,4,4-Trifluoro-1-(4-(((6-methylpyrimidin-4-yl)oxy)methyl)piperidin-1-yl)butan-1-one
  • 4-Cyclobutyl-6-[(1-cyclopropanecarbonylpiperidin-4-yl)methoxy]pyrimidine
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