Regorafenib (BAY 73-4506)

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Names

[ CAS No. ]:
755037-03-7

[ Name ]:
Regorafenib (BAY 73-4506)

[Synonym ]:
BAY734506
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino] carbonyl]amino]-3-fluorophenoxy]-N-methyl-
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
Regorafenib
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
Stivarga
BAY73-4506
4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
BAY 73-4506

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
513.4±50.0 °C at 760 mmHg

[ Melting Point ]:
206.0 to 210.0 °C

[ Molecular Formula ]:
C21H15ClF4N4O3

[ Molecular Weight ]:
482.815

[ Flash Point ]:
264.3±30.1 °C

[ Exact Mass ]:
482.076874

[ PSA ]:
92.35000

[ LogP ]:
5.26

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.616

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
29242990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide
  • 4-Chloro-3-(trifluoromethyl)phenylisocyanate
  • 3-Fluoro-4-nitrophenol
  • 4-Amino-3-fluorophenol

DownStream

  • Regorafenib (Hydrochloride)

Related Compounds

  • Regorafenib Monohydrate
  • (S)-BAY73-6691
  • Niclosamide olamine
  • BAY 73-6691 racemate
  • BAY 73-1449
  • BAY 73-6691
  • Methyl 6-bromo-8-nitroimidazo[1,2-a]pyridine-2-carboxylate
  • 4-(1,3-Thiazol-4-yl)-1,2,3,6-tetrahydropyridine
  • Carbonic acid, 1-methylcyclopropyl 2-pyridinyl ester
  • [(4-Bromo-3-methylphenyl)methyl](propan-2-yl)amine
  • N-Cyclopropyl-N-(1-methyl-2-propen-1-yl)glycine
  • tert-Butyl (S)-3-(4-fluorophenyl)piperazine-1-carboxylate
  • 3-chloro-7-trifluoromethyl-1H-indole-2-carboxylic acid methyl ester
  • 4,8-Dibromo-3,5,6,7-tetrahydro-2-methyl-s-indacen-1(2H)-one
  • 1-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine
  • 1-butyl-5-ethyl-1H-pyrazole-4-carboxylic acid
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