Isradipine

Suppliers

Names

[ Name ]:
Isradipine

[Synonym ]:
isopropyl 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylate
Rebriden
DynaCirc
4-(2,1,3-Benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3-isopropyloxycarbonylpyridine-5-carboxylic Acid Methyl Ester
Esradin
Isrodipine
4-(2,1,3-Benzooxadiazol-4-yl)-2.6-dimethyl-1,4-dihydro-3-isopropyloxycarbonylpyridine-5-carboxylic Acid Methyl Ester
Presca
3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester (9CI)
Dynacrine
MFCD00153820
Rebfiden
Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic AcidMethyl 1-Methylethyl Ester
Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
Iomir
methyl propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3-isopropyloxycarbonyl-pyridine-5-carboxylic acid methyl ester
Clivoten
UNII:YO1UK1S598
4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-pyridine-5-carboxylic acid isopropyl ester
Lomir
4-(2,1,3-benzoxadiazol-4-yl)-2,6-diméthyl-1,4-dihydropyridine-3,5-dicarboxylate de méthyle et de 1-méthyléthyle
3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester
Methyl-1-methylethyl-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarboxylat
Isradipine
methyl 1-methylethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Prescal
Isradipin

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
501.9±60.0 °C at 760 mmHg

[ Melting Point ]:
166-168°C

[ Molecular Formula ]:
C₁₉H₂₁N₃O₅

[ Molecular Weight ]:
371.387

[ Flash Point ]:
257.4±32.9 °C

[ Exact Mass ]:
371.148132

[ PSA ]:
103.55000

[ LogP ]:
3.59

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.566

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: ~26 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Articles

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.

Brain 137(Pt 8) , 2287-302, (2014)

Dopamine midbrain neurons within the substantia nigra are particularly prone to degeneration in Parkinson's disease. Their selective loss causes the major motor symptoms of Parkinson's disease, but th...

Analysis of responses to the TRPV4 agonist GSK1016790A in the pulmonary vascular bed of the intact-chest rat.

Am. J. Physiol. Heart Circ. Physiol. 306(1) , H33-40, (2014)

The transient receptor potential vanilloid 4 (TRPV4) channel is a nonselective cation channel expressed on many cell types, including the vascular endothelium and smooth muscle cells. TRPV4 channels p...

L-type calcium channel blockade alleviates molecular and reversal spatial learning and memory alterations induced by entorhinal amyloid pathology in rats.

Behav. Brain Res. 237 , 190-9, (2013)

The entorhinal cortex (EC) is one of the most vulnerable brain regions that is affected by beta amyloid (Aβ) in the early phases of Alzheimer's disease (AD). Calcium dyshomeostasis is one reason of Aβ...

ISRADIPINE
Isradipine-d6
Isradipine-d3
Isradipine Lactone
Dehydro Isradipine
Isradipine Impurity
2-(10-Phenylanthracen-9-yl)naphtho[2,3-b]benzofuran
Citronellyl ethyl ether, (S)-
[1-(5-Bromothiophen-3-yl)cyclohexyl]methanamine
Ethyl 3-bromo-5-(methylthio)benzoate
(3-Bromo-5-ethylphenyl)(methyl)sulfane
2-(2-Bromo-6-iodophenyl)acetic acid
3-Chloro-2-ethylbenzonitrile
Prenylpiperitol
4-amino-1-[(2R,3R,4R,5R)-3,4-bis[[tert-butyl(dimethyl)silyl]oxy]-5-[[tert-butyl(dimethyl)silyl]oxymethyl]oxolan-2-yl]-5-methylpyrimidin-2-one
11-Benzyl-4-[(2-methylphenyl)methyl]-2,4,7,11-tetrazatricyclo[7.4.0.03,7]trideca-1(9),2-dien-8-one

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