Leflunomide

Suppliers

Names

[ Name ]:
Leflunomide

[Synonym ]:
N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4-carboxamide
Leflunomidum
5-Methyl-N-[4-(trifluormethyl)phenyl]isoxazol-4-carboxamid
Leflunomide
Leflunomida
Arava
lefunamide
MFCD00867593
4-Isoxazolecarboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-
5-methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide
5-méthyl-N-[4-(trifluorométhyl)phényl]isoxazole-4-carboxamide
5-Methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
HWA 486
Leflunomid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
289.3±40.0 °C at 760 mmHg

[ Melting Point ]:
163-168°C

[ Molecular Formula ]:
C₁₂H₉F₃N₂O₂

[ Molecular Weight ]:
270.207

[ Flash Point ]:
128.8±27.3 °C

[ Exact Mass ]:
270.061615

[ PSA ]:
55.13000

[ LogP ]:
1.95

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.541

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P280-P301 + P310 + P330-P305 + P351 + P338-P337 + P313

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
NY2354200

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Gingival pain: an unusual side effect of ziprasidone.

BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013)

The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laborator...

An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis.

Mol. Cancer Ther. 13(10) , 2450-62, (2014)

The growth of new lymphatic vessels (lymphangiogenesis) in tumors is an integral step in the metastatic spread of tumor cells, first to the sentinel lymph nodes that surround the tumor and then elsewh...

SND-117, a sinomenine bivalent alleviates type II collagen-induced arthritis in mice.

Int. Immunopharmacol. 26 , 423-31, (2015)

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that affects about 1% of the population worldwide. RA is mainly manifested by persistent synovitis and progressive joint destruct...