N-FORMYL-N-METHYLHYDRAZINE

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Names

[ CAS No. ]:
758-17-8

[ Name ]:
N-FORMYL-N-METHYLHYDRAZINE

[Synonym ]:
Hydrazine,1-formyl-1-methyl
N-METHYL-N-FORMYLHYDRAZINE
1-Methyl-1-formylhydrazide
Methylformylhydrazine
2-Methyl-2-formylhydrazine
1-Formyl-1-methylhydrazin
Formic acid,methylhydrazide
N-amino-N-methyl-formamide
Formic acid,1-methylhydrazide
N-methylformic hydrazide
N-formyl-N-methylhydrazine
1-formyl-1-methylhydrazine
1-methyl-1-formyl-hydrazine
1-Methylformylhydrazine

Chemical & Physical Properties

[ Density]:
1.061g/cm3

[ Boiling Point ]:
118.6ºC at 760 mmHg

[ Melting Point ]:
219-222 °C

[ Molecular Formula ]:
C₂H₆N₂O

[ Molecular Weight ]:
74.08180

[ Flash Point ]:
25.5ºC

[ Exact Mass ]:
74.04800

[ PSA ]:
46.33000

[ LogP ]:
0.28450

[ Index of Refraction ]:
1.45

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ8940000

CHEMICAL NAME :: Formic acid, methylhydrazide

CAS REGISTRY NUMBER :: 758-17-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C2-H6-N2-O

MOLECULAR WEIGHT :: 74.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 118 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Liver - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 mg/kg/62W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg/40W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 6100 mg/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7840 mg/kg/70W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3360 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3158 mg/kg/94W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3920 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 64 mg/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg/70W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 187 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 158 mg/kg/79W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 umol/plate

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 26,155,1983

Safety Information

[ Hazard Codes ]:
T+

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

monomethylhydrazine
Ethyl formate
Formic Acid
Ethoxymethaniminium chloride
methyl formate

DownStream

6,8-Difluoro-1-(formylmethylamino)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid ethyl ester
pentanal N-methyl-N-formylhydrazone
N-(ethylideneamino)formamide
N-(heptylideneamino)-N-methylformamide
2-Octylidene-1-methylhydrazinecarbaldehyde
N-methyl-N-(nonylideneamino)formamide
N-(benzylideneamino)-N-methylformamide
N-methyl-N-(2-phenylethylideneamino)formamide
N-methyl-N-(pentan-2-ylideneamino)formamide
N-methyl-N-(octan-3-ylideneamino)formamide

Related Compounds

N-formyl-N-benzyloxyamine
N-formyl-N-(2-oxo-2-(p-tolyl)ethyl)formamide
N-Formyl-N-(β-cyanoethyl)-nitramin
N-formyl-N-methoxy-2-methylpropanamide
N-formyl-N-(4-nitro-phenyl)-glycine
N-formyl-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-(R)-tert-leucine-N'-tert-butyl-amide
(2R)-2-{[(1RS,5SR)-5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohex-3-en-1-yl]formamido}-3-methylbutanoic acid
(2R)-1-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohex-3-ene-1-carbonyl]piperidine-2-carboxylic acid
(3S)-1-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohex-3-ene-1-carbonyl]piperidine-3-carboxylic acid
rac-(1R,3S)-3-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido]methyl}-2,2-difluorocyclopropane-1-carboxylic acid
2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]methyl}cyclopropane-1-carboxylic acid
rac-(1R,3S)-3-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]methyl}-2,2-difluorocyclopropane-1-carboxylic acid
2-amino-2-(difluoromethyl)-5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoic acid
2-{2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1H-pyrazol-1-yl]acetyl}-5-oxopyrazolidine-3-carboxylic acid
2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetyl]-5-oxopyrazolidine-3-carboxylic acid
2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanoyl]-5-oxopyrazolidine-3-carboxylic acid

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