N,N-Dimethylpropanamide

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Names

[ CAS No. ]:
758-96-3

[ Name ]:
N,N-Dimethylpropanamide

[Synonym ]:
EINECS 212-064-9
Propionamide, N,N-dimethyl-
Propanamide, N,N-dimethyl-
N,N-Dimethylpropanamide
MFCD00009301

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
176.0±0.0 °C at 760 mmHg

[ Melting Point ]:
-45 °C

[ Molecular Formula ]:
C5H11NO

[ Molecular Weight ]:
101.147

[ Flash Point ]:
62.2±0.0 °C

[ Exact Mass ]:
101.084061

[ PSA ]:
20.31000

[ LogP ]:
-0.22

[ Vapour Pressure ]:
1.1±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.416

[ Stability ]:
Flammable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UE3810000
CHEMICAL NAME :
Propionamide, N,N-dimethyl
CAS REGISTRY NUMBER :
758-96-3
BEILSTEIN REFERENCE NO. :
1740719
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C5-H11-N-O
MOLECULAR WEIGHT :
101.17
WISWESSER LINE NOTATION :
2VN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
875 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 32,539,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
820 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Blood - hemorrhage
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 32,539,1971

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RTECS ]:
UE3810000

[ HS Code ]:
29241900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Propanoyl chloride
  • Dimethylamine
  • 2-Dimethylaminobutan-1-ol
  • Acryloyldimethylamine
  • carbon monoxide
  • lithium,triethylgermanium
  • N,N-Dimethylacetamide
  • lithium,methanidyl-methylidene-diphenyl-λ5-phosphane
  • methyl iodide

DownStream

  • 2-Propionylpyrrole
  • 2-PROPIONYLTHIAZOLE
  • N,N-Dimethylpropionamidedimethylacetale
  • 2-ethylbenzimidazole
  • 1N1&VR
  • di-tert-butyl nitroxide
  • 1-Bromo-2-butanone

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Topotactic conversion of β-helix-layered silicate into AST-type zeolite through successive interlayer modifications.

Chemistry 20(7) , 1893-900, (2014)

AST-type zeolite with a plate morphology can be synthesized by topotactic conversion of a layered silicate (β-helix-layered silicate; HLS) by using N,N-dimethylpropionamide (DPA) to control the layer ...

Conformation of solvent N,N-dimethylpropionamide in the coordination sphere of the zinc(II) ion studied by Raman spectroscopy and DFT calculations.

J. Phys. Chem. A 109(21) , 4862-8, (2005)

Solvation structure of the zinc(II) ion in N,N-dimethylpropionamide (DMPA) was studied by Raman spectroscopy at varying temperature and by quantum mechanical calculations. No significant ion-pair form...

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ACS Appl. Mater. Interfaces 7 , 14369-75, (2015)

Palladium nanosheets with strong near-infrared absorption have been recently demonstrated as promising photothermal agents for photothermal therapy (PTT) of cancers. However, systematic assessments of...


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Related Compounds

  • 2-broMo-N,N-diMethylpropanaMide
  • 3-amino-N,N-dimethylpropanamide
  • 3-bromo-N,N-dimethylpropanamide
  • 2-azido-N,N-dimethylpropanamide
  • 3-Chloro-N,N-diMethylpropanamide
  • 3-hexoxy-N,N-dimethylpropanamide
  • O-(2-methyl-3-phenylbutan-2-yl)hydroxylamine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2,2-Difluoro-2-(5-nitrofuran-2-yl)acetic acid
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • (Cyclopropylmethyl)({6-oxabicyclo[3.2.1]octan-2-yl}methyl)amine
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde