DIMETHYL TUBOCURARINE IODIDE

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Names

[ CAS No. ]:
7601-55-0

[ Name ]:
DIMETHYL TUBOCURARINE IODIDE

[Synonym ]:
metocurine diiodide
Metokuriinijodidi
Metokurinjodid
6,6',7',12'-Tetramethoxy-2,2,2',2'-tetramethyl-tubocurarandiium,Dijodid
6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-tubocuraranium
6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-tubocurarandiium,diiodide
Dimethyltubocurarine Iodide
Metubine
Methyl-curarin
Mutubine Iodide
O,O'-dimethyl-tubocurarine diiodide
METOCURINE IODIDE

Chemical & Physical Properties

[ Molecular Formula ]:
C40H48I2N2O6

[ Molecular Weight ]:
906.62800

[ Exact Mass ]:
906.16000

[ PSA ]:
55.38000

[ LogP ]:
1.37720

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YO3700000
CHEMICAL NAME :
Tubocuraranium, 6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-, diiodide
CAS REGISTRY NUMBER :
7601-55-0
LAST UPDATED :
199107
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C40-H48-N2-O6.2I
MOLECULAR WEIGHT :
906.70
WISWESSER LINE NOTATION :
T D6 I6 I-6 R6-18-66 D- D-- I-- R- 2AI- H& CO JK QO B&K&T&&TT&J J1 J1 OO1 SO1 B&1 B&1 G&O1 H&

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
150 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,109,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
370 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,109,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
35 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 34,516,1949
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
230 ug/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 244,493,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
32 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 34,516,1949
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 34,516,1949

Safety Information

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methyl iodide
  • d-tubocurarine chloride

DownStream

Related Compounds

  • Dimethyl-d-tubocurarine Iodide
  • Thiazolium,3,4-dimethyl-, iodide (1:1)
  • Acridinium,9,10-dimethyl-, iodide (1:1)
  • Benzothiazolium,2,3-dimethyl-, iodide
  • Pyridinium,1,4-dimethyl-, iodide (1:1)
  • Piperidinium,1,1-dimethyl-, iodide (1:1)
  • Benzenemethanamine, 2,4,5-trichloro-I+/--cyclopropyl-
  • 2-(2-Phenylhydrazinylidene)cyclohexanecarbonitrile
  • tert-butyl N-[4-(carbamimidoylmethyl)-2-methylphenyl]carbamate
  • 2,2-dimethyl-3-(1H-pyrazol-4-yl)propanoic acid
  • 4-(4-Chlorophenyl)-1-(6-methylpyrazin-2-yl)piperidin-4-ol
  • 3-(3-Bromo-4-methylthiophen-2-yl)prop-2-en-1-amine
  • 3-[(2-Chloroquinolin-3-yl)oxy]propan-1-amine
  • methyl 2-amino-2-[1-(1-methyl-1H-imidazol-2-yl)cyclopropyl]acetate
  • (1S)-1-(1-ethyl-1H-pyrazol-3-yl)-2,2,2-trifluoroethan-1-ol
  • 3-Amino-2-(6-chloro-5-methylpyridin-3-yl)-2-methylpropan-1-ol
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