Colchicine, 10-(benzylamino)-10-demethoxy-

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Names

[ CAS No. ]:
76129-15-2

[ Name ]:
Colchicine, 10-(benzylamino)-10-demethoxy-

[Synonym ]:
N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-benzylamino-9-oxobenzo[a]heptalen-7-yl]acetamide
N-<5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-<(phenylmethyl)amino>benzo<a>heptalen-7-yl>-(S)-acetamide
10-(Benzylamino)-10-demethoxycolchicine
N-((S)-10-Benzylamino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid
(S)-7-Acetylamino-10-benzylamino-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on
N-((S)-10-benzylamino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-9-oxo-10-benzylaminobenzo[a]heptalen-7-yl]acetamide

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Boiling Point ]:
794.2ºC at 760 mmHg

[ Molecular Formula ]:
C28H30N2O5

[ Molecular Weight ]:
474.54800

[ Flash Point ]:
434.1ºC

[ Exact Mass ]:
474.21500

[ PSA ]:
85.89000

[ LogP ]:
4.93900

[ Index of Refraction ]:
1.622

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC8755000
CHEMICAL NAME :
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-((phe nylmethyl)amino)benzo (a) heptalen-7-yl)-, (S)-
CAS REGISTRY NUMBER :
76129-15-2
BEILSTEIN REFERENCE NO. :
3185612
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C28-H30-N2-O5
MOLECULAR WEIGHT :
474.60
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 DO1 JMV1 NM1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Colchicine
  • Benzylamine

DownStream

Related Compounds

  • 10-(benzylamino)-10,10a-dihydroindeno[1,2-b]quinolin-11-one
  • Colchicine, 10-demethoxy-17-hydroxy-10-methylthio-
  • N-[(7S)-10-(diethylamino)-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
  • Thiocolchicine
  • Acetamide, 2-chloro-N-[5,6,7,9-tetrahydro-1,2, 3-trimethoxy-10-(methylthio)-9-oxobenz[a]heptalen-7-yl]-, (S)-
  • 9,10,10-trinitro-9H-anthracene
  • 2-(2-Cyano-4-(difluoromethyl)-6-fluorophenyl)acetic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide