Colchicine, 10-(benzylamino)-10-demethoxy-

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Names

[ CAS No. ]:
76129-15-2

[ Name ]:
Colchicine, 10-(benzylamino)-10-demethoxy-

[Synonym ]:
N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-benzylamino-9-oxobenzo[a]heptalen-7-yl]acetamide
N-<5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-<(phenylmethyl)amino>benzo<a>heptalen-7-yl>-(S)-acetamide
10-(Benzylamino)-10-demethoxycolchicine
N-((S)-10-Benzylamino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid
(S)-7-Acetylamino-10-benzylamino-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on
N-((S)-10-benzylamino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-9-oxo-10-benzylaminobenzo[a]heptalen-7-yl]acetamide

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Boiling Point ]:
794.2ºC at 760 mmHg

[ Molecular Formula ]:
C28H30N2O5

[ Molecular Weight ]:
474.54800

[ Flash Point ]:
434.1ºC

[ Exact Mass ]:
474.21500

[ PSA ]:
85.89000

[ LogP ]:
4.93900

[ Index of Refraction ]:
1.622

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC8755000
CHEMICAL NAME :
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-((phe nylmethyl)amino)benzo (a) heptalen-7-yl)-, (S)-
CAS REGISTRY NUMBER :
76129-15-2
BEILSTEIN REFERENCE NO. :
3185612
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C28-H30-N2-O5
MOLECULAR WEIGHT :
474.60
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 DO1 JMV1 NM1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Colchicine
  • Benzylamine

DownStream

Related Compounds

  • 10-(benzylamino)-10,10a-dihydroindeno[1,2-b]quinolin-11-one
  • Colchicine, 10-demethoxy-17-hydroxy-10-methylthio-
  • N-[(7S)-10-(diethylamino)-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
  • Thiocolchicine
  • Acetamide, 2-chloro-N-[5,6,7,9-tetrahydro-1,2, 3-trimethoxy-10-(methylthio)-9-oxobenz[a]heptalen-7-yl]-, (S)-
  • 9,10,10-trinitro-9H-anthracene
  • 9-(Azetidin-3-yl)-9H-purin-6-amine
  • [1-(Pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl]methanol
  • (1-Piperidin-4-yl-1H-[1,2,3]triazol-4-yl)-methanol
  • [1-(piperidin-3-yl)-1H-1,2,3-triazol-4-yl]methanol
  • 6-Methyl-4-(piperidin-3-yloxy)-2H-pyran-2-one
  • 3-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)piperidine
  • Methyl 4-(2H-1,2,3-triazol-2-yl)pyrrolidine-2-carboxylate
  • Methyl 4-(1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylate
  • 2-({5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}oxy)propan-1-amine
  • 4-[(1-Aminopropan-2-yl)oxy]-1,6-dimethyl-1,2-dihydropyridin-2-one
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