8-hydroxy-1-methoxy-3-methylnaphtho[3,2-c]isochromene-5,7,12-trione

Names

[ CAS No. ]:
76191-51-0

[ Name ]:
8-hydroxy-1-methoxy-3-methylnaphtho[3,2-c]isochromene-5,7,12-trione

[Synonym ]:
Antibiotic WS5995A
WS-5995 A

Chemical & Physical Properties

[ Density]:
1.53g/cm3

[ Boiling Point ]:
623.3ºC at 760 mmHg

[ Molecular Formula ]:
C19H12O6

[ Molecular Weight ]:
336.29500

[ Flash Point ]:
232.9ºC

[ Exact Mass ]:
336.06300

[ PSA ]:
93.81000

[ LogP ]:
2.59100

[ Index of Refraction ]:
1.701

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DI2265000
CHEMICAL NAME :
5H-Benzo(d)naphtho(2,3-b)pyran-5,7,12-trione, 8-hydroxy-1-methoxy-3-methyl-
CAS REGISTRY NUMBER :
76191-51-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H12-O6
MOLECULAR WEIGHT :
336.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,1107,1980
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,1107,1980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,8-dimethoxy-3-methyl-7,12-dihydro-5H-dibenzo[c,g]chromene-5,7,12-trione
  • 2-(3-hydroxymethoxy-1,4-dioxo-1,4-dihydro-2-naphthyl)-3-methyl-5-methoxybenzoic acid
  • 4,8-dihydroxynaphthalene-1,2-dione

DownStream

Related Compounds

  • 4-Methyl-5-(1,1,2,2-tetrafluoroethyl)-4H-1,2,4-triazole-3-thiol
  • 1-Cyclobutyl-3-oxocyclobutane-1-carboxylic acid
  • 5-(Oxan-3-yl)-1,3-oxazol-2-amine
  • 4-ethyl-5-(2-methylbutan-2-yl)-4H-1,2,4-triazole-3-thiol
  • 2-Chloro-6-(3-chloro-4-fluorophenyl)isonicotinonitrile
  • 3-(3-Bromophenyl)-4-isopropyl-4H-1,2,4-triazole
  • 4-Bromo-6-[4-(trifluoromethyl)phenyl]-3-pyridazinamine
  • 4-Bromo-6-(4-fluorophenyl)pyridazin-3-amine
  • 4-tert-butyl-3-phenyl-4H-1,2,4-triazole
  • 3-[3-Chloro-5-(trifluoromethyl)phenyl]butan-1-amine
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