Diethyl phosphite

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Names

[ CAS No. ]:
762-04-9

[ Name ]:
Diethyl phosphite

[Synonym ]:
EINECS 212-091-6
MFCD00044573
Diethyl phosphite
diethoxy(oxo)phosphanium

Chemical & Physical Properties

[ Density]:
1.072 g/mL at 25 °C(lit.)

[ Boiling Point ]:
50-51 °C2 mm Hg(lit.)

[ Melting Point ]:
-70 °C

[ Molecular Formula ]:
C4H11O3P

[ Molecular Weight ]:
138.10200

[ Flash Point ]:
180 °F

[ Exact Mass ]:
138.04500

[ PSA ]:
59.00000

[ LogP ]:
1.44910

[ Index of Refraction ]:
n20/D 1.407(lit.)

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, strong bases. May decompose on exposure to moisture. Combustible.

[ Water Solubility ]:
miscible (hydrolysis)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TG7875000
CHEMICAL NAME :
Phosphorous acid, diethyl ester
CAS REGISTRY NUMBER :
762-04-9
BEILSTEIN REFERENCE NO. :
0605759
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C4-H11-O3-P
MOLECULAR WEIGHT :
138.12
WISWESSER LINE NOTATION :
2OPQO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ALBRW* Albright & Wilson Inc. (P.O. Box 26229, Richmond, VA 23260-6229) Volume(issue)/page/year: #OPB-3,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2020 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82805 No. of Facilities: 41 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 352 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82805 No. of Facilities: 84 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 505 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38;R43

[ Safety Phrases ]:
S26-S36/37/39-S37/39-S28-S27

[ RIDADR ]:
NA 1993 / PGIII

[ WGK Germany ]:
1

[ RTECS ]:
TG7875000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Triethyl phosphite
  • Ethanol
  • Diethyl chlorophosphate
  • Diethyl (2-bromoethyl)phosphonate
  • (diethoxyphosphoryl)methyl triflate
  • Diethyl phosphite
  • 3-Nitrobenzaldehyde
  • 4-Methoxybenzaldehyde
  • Cinnamaldehyde
  • Propionaldehyde

DownStream

  • 1-(bromomethyl)-4-(diethoxyphosphorylmethyl)benzene
  • Tetraethyl(ethoxycarbonylethylidene)bisphosphonate
  • ethyl (E)-3-diethoxyphosphorylprop-2-enoate
  • methyl 2-diethoxyphosphoryloxy-3,3,3-trifluoropropanoate
  • [diethoxyphosphoryl(methoxy)methyl]benzene
  • hexylphosphonic acid diethyl ester
  • 5-(diethoxyphosphorylmethyl)undecane
  • diethyl (2,4-dibutyldecyl)phosphonate
  • diethoxyphosphoryl(naphthalen-2-yl)methanol
  • bis(2-chloroethyl)phosphite

Articles

Silver-catalyzed radical phosphonofluorination of unactivated alkenes.

J. Am. Chem. Soc. 135(38) , 14082-5, (2013)

We report herein a mild and catalytic phosphonofluorination of unactivated alkenes. With catalysis by AgNO3, the condensation of various unactivated alkenes with diethyl phosphite and Selectfluor reag...

Efficient cross-coupling of functionalized arylzinc halides catalyzed by a nickel chloride-diethyl phosphite system.

Org. Lett. 7(22) , 4871-4, (2005)

[reaction: see text] The combination of diethyl phosphite and DMAP as ligands for nickel in an 8:1 THF-N-ethylpyrrolidinone (NEP) mixture allows a very efficient cross-coupling reaction to be performe...

A method for synthesis of homoallylic bromide.

J. Org. Chem. 78(12) , 5918-24, (2013)

Cyclopropyl Grignard reagents react with carbonyl compounds in the presence of diethyl phosphite to give homoallylic bromides. The reaction is effectively carried out under mild conditions in a one-po...


More Articles

Related Compounds

  • Diethyl phosphite
  • diethyl phosphite
  • benzyl diethyl phosphite
  • Acetyl Diethyl Phosphite
  • methyl diethyl phosphite
  • Lithium diethyl phosphite
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