Monochlorobimane

Names

[ CAS No. ]:
76421-73-3

[ Name ]:
Monochlorobimane

[Synonym ]:
7-(chloromethyl)-1,2,6-trimethylpyrazolo[1,2-a]pyrazole-3,5-dione
Chlorobimane
Monochlorobimane

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
314.9ºC at 760 mmHg

[ Melting Point ]:
135-136ºC(lit.)

[ Molecular Formula ]:
C₁₀H₁₁ClN₂O₂

[ Molecular Weight ]:
226.66000

[ Flash Point ]:
144.2ºC

[ Exact Mass ]:
226.05100

[ PSA ]:
42.96000

[ LogP ]:
0.86100

[ Index of Refraction ]:
1.61

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

9,10-dioxa-syn-(hydroxymethyl,methyl)(methyl,methyl)bimane
Bromobimane
syn-(Methyl,methyl)bimane

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3.

Mol. Cell. Biol. 35 , 3646-56, (2015)

Increased production of mitochondrion-derived reactive oxygen species (ROS) is characteristic of a metabolic shift observed during malignant transformation. While the exact sources and roles of ROS in...

Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA.

Biochim. Biophys. Acta 1840(9) , 2851-61, (2014)

Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis wa...

All-trans retinoic acid prevents oxidative stress-induced loss of renal tight junction proteins in type-1 diabetic model.

J. Nutr. Biochem. 26 , 441-54, (2015)

We previously reported that diabetes decreased the expression of renal tight junction (TJ) proteins claudin-5 in glomerulus, and claudin-2 and occludin in proximal tubule through an oxidative stress d...

monochlorobimane
N-(2-(methylthio)-4-phenylthiazol-5-yl)-3-phenylpropanamide
2-oxo-N-(4-(2-oxo-2-((1-phenylethyl)amino)ethyl)thiazol-2-yl)-1,2-dihydropyridine-3-carboxamide
2-(4-(3-(2-Methylpyridin-4-YL)pyridin-2-yloxy)benzyl)-1H-benzo[D]imidazole
(1H-Benzo[D]imidazol-2-YL)(4-(3-(piperidin-1-YL)pyridin-2-yloxy)phenyl)methanone
4-Ethoxyphenyl 2-bromobutanoate
2-Amino-N-(2-ethoxyphenyl)-4-(methylsulfonyl)butanamide
1-(4-((1-(4-methoxyphenyl)-1H-tetrazol-5-yl)methyl)piperazin-1-yl)-2-phenoxypropan-1-one
2-phenyl-1-(4-((1-(p-tolyl)-1H-tetrazol-5-yl)methyl)piperazin-1-yl)butan-1-one
1-phenyl-4-(4-((1-(p-tolyl)-1H-tetrazol-5-yl)methyl)piperazine-1-carbonyl)pyrrolidin-2-one
2-bromo-N-(2-ethylphenyl)butanamide