3H-1,4-BENZODIAZEPIN-3-OL, 7-CHLORO-2-(DIMETHYLAMINO)-5-PHENYL-

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Names

[ CAS No. ]:
76458-47-4

[ Name ]:
3H-1,4-BENZODIAZEPIN-3-OL, 7-CHLORO-2-(DIMETHYLAMINO)-5-PHENYL-

[Synonym ]:
7-Chloro-2-dimethylamino-3-hydroxy-5-phenyl-3H-1,4-benzodiazepine
3H-1,4-BENZODIAZEPIN-3-OL,7-CHLORO-2-(DIMETHYLAMINO)-5-PHENYL

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
479.4ºC at 760 mmHg

[ Molecular Formula ]:
C17H16ClN3O

[ Molecular Weight ]:
313.78100

[ Flash Point ]:
243.7ºC

[ Exact Mass ]:
313.09800

[ PSA ]:
48.19000

[ LogP ]:
1.97220

[ Index of Refraction ]:
1.638

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE9735000
CHEMICAL NAME :
3H-1,4-Benzodiazepin-3-ol, 7-chloro-2-(dimethylamino)-5-phenyl-
CAS REGISTRY NUMBER :
76458-47-4
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H16-Cl-N3-O
MOLECULAR WEIGHT :
313.81
WISWESSER LINE NOTATION :
T67 GN JN HHJ CG HN1&1 IQ KR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 37,343,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Acetoxy-7-chloro-2-dimethylamino-5-phenyl-3H-1,4-benzodiazepine
  • 7-Chloro-2-(dimethylamino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide
  • 3-acetossi-7-cloro-5-fenil-2-(di-4-morfolinil)fosfinilossi-3H-1,4-benzodiazepina
  • 2H-1,4-Benzodiazepin-2-one,3-(acetyloxy)-7-chloro-1,3-dihydro-5-phenyl-

DownStream

Related Compounds

  • Tert-butyl N-[2-(3-azabicyclo[3.2.0]heptan-1-yl)ethyl]carbamate
  • 2,2-Difluoro-N-phenylspiro[2.2]pentane-1-carboxamide
  • 2-Cyclopropyl-4-methylthiazole-5-sulfonyl chloride
  • Methyl 6-(aminomethyl)-5-oxaspiro[3.5]nonane-2-carboxylate
  • Tert-butyl (2R,3R)-6-oxospiro[2.3]hexane-2-carboxylate
  • Tert-butyl-dimethyl-[2-methyl-4-(2-trimethylsilylethynyl)phenoxy]silane
  • Methyl 3-aminospiro[3.3]heptane-1-carboxylate
  • 1,1-Dimethyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]silolane-3-carboxylic acid
  • Tert-butyl 3-(bromomethylidene)cyclobutane-1-carboxylate
  • Tert-butyl 5-(azidomethyl)-1,3-dihydroisoindole-2-carboxylate
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