Guanosine 3',5'-cyclic monophosphate

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Names

[ CAS No. ]:
7665-99-8

[ Name ]:
Guanosine 3',5'-cyclic monophosphate

[Synonym ]:
2-Amino-6-oxo-6,9-dihydro-1H-purine 3-oxide
3',5'-cyclic guanosine monophosphate
guanine-3-N-oxide
2-Amino-1,7-dihydro-6H-purin-6-one 3-oxide
guanine-N3-oxide
MFCD00070129
purine-N-oxide
guanosine 3',5'-monophosphate
2-amino-6H-purin-6-one 3-oxide
EINECS 231-641-6
Guanin-3-N-oxid
3',5'-cyclic monophosphate of guanosine
2-amino-3-oxy-1,7(9)-dihydro-purin-6-one
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE
guanosine 3',5'-cyclic monophosphate

Chemical & Physical Properties

[ Density]:
2.64g/cm3

[ Boiling Point ]:
792.7ºC at 760 mmHg

[ Molecular Formula ]:
C10H12N5O7P

[ Molecular Weight ]:
345.20500

[ Flash Point ]:
433.2ºC

[ Exact Mass ]:
345.04700

[ PSA ]:
184.62000

[ Index of Refraction ]:
2.064

[ Storage condition ]:
−20°C

[ Water Solubility ]:
1% sodium bicarbonate: 50 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Guanosine
  • guanosine 5'-(tetrahydrogen triphosphate)
  • [7-(carboxymethoxy)coumarin-4-yl]methyl ester of cGMP
  • [7-(carboxymethoxy)coumarin-4-yl]methyl ester of cGMP
  • cyclic guanosine-3',5'-monophosphate [6,7-bis(carboxymethoxy)coumarin-4-yl]methyl ester
  • cyclic guanosine-3',5'-monophosphate [6,7-bis(carboxymethoxy)coumarin-4-yl]methyl ester

DownStream

  • 8-bromo-3',5'-cyclic GMP
  • guanosine 3'-(dihydrogen phosphate)
  • Guanosine
  • 5'-Guanylic acid

Articles

H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway.

Oncotarget 6(9) , 6877-86, (2015)

High doses of the organic nitrate glyceryl trinitrate (GTN), a nitric oxide (NO) donor, are known to trigger apoptosis in human cancer cells. Here, we show that such a cytotoxic effect can be obtained...

Atrial natriuretic peptide inhibits cell cycle activity of embryonic cardiac progenitor cells via its NPRA receptor signaling axis.

Am. J. Physiol. Cell Physiol. 308(7) , C557-69, (2015)

The biological effects of atrial natriuretic peptide (ANP) are mediated by natriuretic peptide receptors (NPRs), which can either activate guanylyl cyclase (NPRA and NPRB) or inhibit adenylyl cyclase ...

Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults.

Clin. Exp. Immunol. 182 , 289-301, (2015)

VRC-HIVMAB060-00-AB (VRC01) is a broadly neutralizing HIV-1 monoclonal antibody (mAb) isolated from the B cells of an HIV-infected patient. It is directed against the HIV-1 CD4 binding site and is cap...


More Articles

Related Compounds

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  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
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  • tert-Butyl-DL-alanine
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  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine