4-Hydroxybenzonitrile

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Names

[ CAS No. ]:
767-00-0

[ Name ]:
4-Hydroxybenzonitrile

[Synonym ]:
para-hydroxybenzonitrile
p-hydroxybenzoic hydrazide
4-Cyanophenol
4-hydroxybenzhydrazide
Benzonitrile, 4-hydroxy-
p-Hydroxybenzhydrazide
p-hydroxybenzoic acid hydrazide
p-Hydroxybenzonitrile
p-hydroxybenzoylhydrazine
4-Hydroxybenzoic acid hydrazide
4-Hydroxybenzonitrile
EINECS 212-175-2
MFCD00002312
4-hydroxybenzoic hydrazide
P-CYANOPHENOL
4-hydroxybenzoylhydrazine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
281.2±23.0 °C at 760 mmHg

[ Melting Point ]:
110-113 °C(lit.)

[ Molecular Formula ]:
C₇H₅NO

[ Molecular Weight ]:
119.121

[ Flash Point ]:
123.9±22.6 °C

[ Exact Mass ]:
119.037117

[ PSA ]:
44.02000

[ LogP ]:
1.60

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI4375000

CHEMICAL NAME :: Benzonitrile, p-hydroxy-

CAS REGISTRY NUMBER :: 767-00-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H5-N-O

MOLECULAR WEIGHT :: 119.13

WISWESSER LINE NOTATION :: QR DCN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 41,391,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S45-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DI4375000

[ Packaging Group ]:
I; II; III

[ Hazard Class ]:
6.1

[ HS Code ]:
29269095

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Benzaldehyde, 4-hydroxy-, oxime
4-hydroxybenzaldehyde
4-Iodobenzonitrile
4-Cyanophenylboronic acid
4-Amidinophenol hydrochloride
Benzonitrile,4-(2-propen-1-yloxy)-
4-(Benzyloxy)benzonitrile
4-Hydroxybenzyl alcohol
4-Hydroxyphenylboronic acid
Benzyl cyanide

DownStream

4-(2-methoxyethoxymethoxy)benzonitrile
3-(4-Cyanophenoxy)propionic Acid
3-(4-CARBAMOYLPHENOXY)PROPIONIC ACID
2-Acetyl-4-cyanophenol
4-Cyanophenyl 4-pentylbenzoate
4-propoxybenzonitrile
4-(2-OXIRANYLMETHOXY)BENZENECARBONITRILE
4-(Benzyloxy)benzonitrile
4-Amidinophenol hydrochloride
4-Cyanophenyl 4'-methylbenzoate

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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