4-Hydroxybenzonitrile

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Names

[ CAS No. ]:
767-00-0

[ Name ]:
4-Hydroxybenzonitrile

[Synonym ]:
para-hydroxybenzonitrile
p-hydroxybenzoic hydrazide
4-Cyanophenol
4-hydroxybenzhydrazide
Benzonitrile, 4-hydroxy-
p-Hydroxybenzhydrazide
p-hydroxybenzoic acid hydrazide
p-Hydroxybenzonitrile
p-hydroxybenzoylhydrazine
4-Hydroxybenzoic acid hydrazide
4-Hydroxybenzonitrile
EINECS 212-175-2
MFCD00002312
4-hydroxybenzoic hydrazide
P-CYANOPHENOL
4-hydroxybenzoylhydrazine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
281.2±23.0 °C at 760 mmHg

[ Melting Point ]:
110-113 °C(lit.)

[ Molecular Formula ]:
C7H5NO

[ Molecular Weight ]:
119.121

[ Flash Point ]:
123.9±22.6 °C

[ Exact Mass ]:
119.037117

[ PSA ]:
44.02000

[ LogP ]:
1.60

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DI4375000
CHEMICAL NAME :
Benzonitrile, p-hydroxy-
CAS REGISTRY NUMBER :
767-00-0
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C7-H5-N-O
MOLECULAR WEIGHT :
119.13
WISWESSER LINE NOTATION :
QR DCN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 41,391,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S45-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DI4375000

[ Packaging Group ]:
I; II; III

[ Hazard Class ]:
6.1

[ HS Code ]:
29269095

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzaldehyde, 4-hydroxy-, oxime
  • 4-hydroxybenzaldehyde
  • 4-Iodobenzonitrile
  • 4-Cyanophenylboronic acid
  • 4-Amidinophenol hydrochloride
  • Benzonitrile,4-(2-propen-1-yloxy)-
  • 4-(Benzyloxy)benzonitrile
  • 4-Hydroxybenzyl alcohol
  • 4-Hydroxyphenylboronic acid
  • Benzyl cyanide

DownStream

  • 4-(2-methoxyethoxymethoxy)benzonitrile
  • 3-(4-Cyanophenoxy)propionic Acid
  • 3-(4-CARBAMOYLPHENOXY)PROPIONIC ACID
  • 2-Acetyl-4-cyanophenol
  • 4-Cyanophenyl 4-pentylbenzoate
  • 4-propoxybenzonitrile
  • 4-(2-OXIRANYLMETHOXY)BENZENECARBONITRILE
  • 4-(Benzyloxy)benzonitrile
  • 4-Amidinophenol hydrochloride
  • 4-Cyanophenyl 4'-methylbenzoate

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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Related Compounds

  • 4-hydroxybenzonitrile
  • 3-IODO-4-HYDROXYBENZONITRILE
  • 2-bromo-4-hydroxybenzonitrile
  • 3-amino-4-hydroxybenzonitrile
  • 3-nitro-4-hydroxybenzonitrile
  • 3-bromo-4-hydroxybenzonitrile
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Bromo-8-azabicyclo[3.2.1]octan-3-one
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide