(D-2-Nal6)-LHRH acetate salt

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Names

[ Name ]:
(D-2-Nal6)-LHRH acetate salt

[Synonym ]:
(2S)-N-(2-amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-(2-methylpropyl)-8-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxopyrrolidin-2-yl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}pyrrolidine-2-carboxamide (non-preferred name)
Nacenyl
(2S)-N-(2-Amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-isobutyl-8-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxopyrrolidin-2-yl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}pyrrolidine-2-carboxamide (non-preferred name)
Nafareline
UNII:1X0094V6JV
Synarel
(2S)-N-(2-Amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-isobutyl-8-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxo-2-pyrrolidinyl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}-2-pyrrolidinecarboxamide
6-(3-(2-Naphthalenyl)-D-alanine)luteinizing Hormone-releasing Factor
glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthalenyl)-D-alanyl-L-leucyl-L-arginyl-L-prolyl-
Synrelina
Nasanyl
Nafarelin Acetate

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₆₆H₈₃N₁₇O₁₃

[ Molecular Weight ]:
1322.471

[ Exact Mass ]:
1321.635620

[ PSA ]:
472.13000

[ LogP ]:
0.89

[ Index of Refraction ]:
1.711

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OK6371150

CHEMICAL NAME :: Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine)-

CAS REGISTRY NUMBER :: 76932-56-4

LAST UPDATED :: 199703

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C66-H83-N17-O13

MOLECULAR WEIGHT :: 1322.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 448 ug/kg/8W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in potassium

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 347,333,1996

Related Compounds

(D-Ala6)-LHRH acetate salt
(D-Ser(tBu)6,AzaGly10)-LHRH acetate salt
(Glu1,D-Ser(tBu)6,AzaGly10)-LHRH acetate salt
(Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH acetate salt
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH acetate salt
(Des-Pyr1,D-Ser(tBu)6,AzaGly10)-LHRH acetate salt
4-(3-Chloro-4-fluorophenyl)picolinic acid
5-(3-Chloro-4-fluorophenyl)picolinic acid
6-(2,4,6-Trifluorophenyl)picolinic acid
6-[Benzo(b)thiophen-2-yl]nicotinic acid
6-[Benzo(b)thiophen-2-yl]picolinic acid
2-Amino-5-[benzo(b)thiophen-2-yl]isonicotinic acid
2-Amino-5-[benzo(B)thiophen-2-YL]nicotinic acid
5-[Benzo(B)thiophen-2-YL]-2-hydroxynicotinic acid
5-[Benzo(b)thiophen-2-yl]-2-hydroxyisonicotinic acid
5-[Benzo(b)thiophen-2-yl]-6-hydroxynicotinic acid

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