beta-Estradiol 17-hemisuccinate

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Names

[ Name ]:
beta-Estradiol 17-hemisuccinate

[Synonym ]:
17beta-Estradiol hemisuccinate
1,3,5(10)-Estratriene-3,17beta-diol 17-hemisuccinate
4-{[(14beta,17alpha)-3-Hydroxyestra-1,3,5(10)-Trien-17-Yl]oxy}-4-Oxobutanoic Acid
Eutocol (TN)
4-{[(17β)-3-Hydroxyestra-1,3,5(10)-trien-17-yl]oxy}-4-oxobutanoic acid
17BETA-ESTRADIOL 17-HEMISUCCINATE
Estradiol-17-hemisuccinate
Butanedioic acid, mono[(17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl] ester
beta-Estradiol 17-hemisuccinate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
570.1±50.0 °C at 760 mmHg

[ Melting Point ]:
162-164°C (lit.)

[ Molecular Formula ]:
C₂₂H₂₈O₅

[ Molecular Weight ]:
372.455

[ Flash Point ]:
198.7±23.6 °C

[ Exact Mass ]:
372.193665

[ PSA ]:
83.83000

[ LogP ]:
4.64

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.598

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332-H351

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-40

[ Safety Phrases ]:
22-36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Succinic anhydride
beta-Estradiol

DownStream

Articles

Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats.

J. Neuroimmunol. , (2008)

Estrogen has been shown to attenuate the inflammatory response following injury or lipopolysaccharide treatment in several organ systems. Estrogen's actions are transduced through two estrogen recepto...

Steroid-bovine serum albumin conjugates: molecular characterization and their interaction with androgen and estrogen receptors.

J. Steroid Biochem. 24(5) , 1017-31, (1986)

Conjugates of testosterone-3-carboxymethyloxime (T-3-CMO), testosterone-17-hemisuccinate (T-17-HS), 17 beta-estradiol-6-carboxymethyloxime (E-6-CMO), or 17 beta-estradiol-17-hemisuccinate (E-17-HS) an...

Prevention of bridge binding in immunoassays: a general estradiol tracer structure.

J. Steroid Biochem. 32(2) , 251-7, (1989)

Iodinated estradiol tracers were synthesized with three different bridges connecting the radiolabelled moiety to the steroid core: Hemisuccinate, carboxymethyloxime and amide. Taking these iodinated t...

beta-Estradiol 17-propionate
ethinyl estradiol 17-hemisuccinate
β-Estradiol 17-acetate
beta-Estradiol
N-(estradiol-17 beta-succinylaminohexyl)-N'-fluoresceinyl-thiourea
17β-Estradiol 17-(2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester)
4-(5-{1-[(4-Fluorophenyl)methyl]piperidin-3-yl}-1,2,4-oxadiazol-3-yl)pyridine
4-(5-{1-[(3,5-Dimethyl-1,2-oxazol-4-yl)methyl]piperidin-3-yl}-1,2,4-oxadiazol-3-yl)pyridine
4-{5-[1-(Furan-2-carbonyl)piperidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine
4-{5-[1-(Thiophene-2-carbonyl)piperidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine
N-(2,5-difluorophenyl)-3-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
N-[(4-methoxyphenyl)methyl]-3-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
4-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-N-[(4-methoxyphenyl)methyl]piperidine-1-carboxamide
4-[5-({1-[(3-Fluoro-4-methoxyphenyl)methyl]piperidin-4-yl}methyl)-1,2,4-oxadiazol-3-yl]pyridine
N-(4-ethylphenyl)-2-(4-{[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]methyl}piperidin-1-yl)acetamide
4-[5-({1-[(4-Fluorophenyl)methyl]piperidin-4-yl}methyl)-1,2,4-oxadiazol-3-yl]pyridine

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