5,5-Dimethylimidazolidine-2,4-dione

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Names

[ CAS No. ]:
77-71-4

[ Name ]:
5,5-Dimethylimidazolidine-2,4-dione

[Synonym ]:
MFCD00005266
2,4-Imidazolidinedione, 5,5-dimethyl-
5,5-Dimethylhydantoin
EINECS 201-051-3
5,5-Dimethyl hydantoin
5,5-dimethylimidazolidine-2,4-dione
5,5-Dimethyl-2,4-imidazolidinedione

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Melting Point ]:
175-180ºC

[ Molecular Formula ]:
C5H8N2O2

[ Molecular Weight ]:
128.129

[ Flash Point ]:
193ºC

[ Exact Mass ]:
128.058578

[ PSA ]:
58.20000

[ LogP ]:
-0.66

[ Index of Refraction ]:
1.449

[ Water Solubility ]:
H2O: 0.1 g/mL hot, clear | soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MU0977000
CHEMICAL NAME :
Hydantoin, 5,5-dimethyl-
CAS REGISTRY NUMBER :
77-71-4
BEILSTEIN REFERENCE NO. :
0002827
LAST UPDATED :
199701
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C5-H8-N2-O2
MOLECULAR WEIGHT :
128.15
WISWESSER LINE NOTATION :
T5MVMV EHJ E1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7800 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - withdrawal Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(6),76,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,723,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(5),69,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
12660 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(6),76,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
8430 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - withdrawal Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(6),76,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
5600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(5),69,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
15950 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(5),69,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2464 mg/kg/22W-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(5),69,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1156 No. of Facilities: 230 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 1125 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ WGK Germany ]:
2

[ RTECS ]:
MU0977000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • aldehydo-2,3:4,5-di-O-isopropylidene-D-arabinose
  • (2,2,7,7-Tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d] pyran-5-yl)methanol (non-preferred name)
  • Sodium cyanide
  • Acetone
  • 1,3-Dibromo-5,5-dimethylhydantoin
  • 1α,3β,24(R)-triethoxycarbonyloxycholest-5-ene
  • (1alpha,3beta)-cholest-5-ene-1,3-diyl diacetate
  • 1α,3β-diethoxycarbonyloxycholest-5-ene
  • 1α,3β,24-triacetoxycholest-5-ene

DownStream

  • 1,3-ditert-butyl-5,5-dimethylimidazolidine-2,4-dione
  • Diethyl 1,2-hydrazinedicarboxylate
  • 2,4-Imidazolidinedione,3,3'-(1,6-hexanediyl)bis[5,5-dimethyl-
  • 1-[(5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)methyl]-5,5-dimethylimidazolidine-2,4-dione
  • 1,5,5-TRIMETHYLHYDANTOIN
  • 1,3-Dibromo-5,5-dimethylhydantoin
  • 2-Aminoisobutyric acid
  • Ammonia

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 3-iodo-5,5-dimethylimidazolidine-2,4-dione
  • 1-bromo-5,5-dimethylimidazolidine-2,4-dione
  • 3-ethyl-5,5-dimethylimidazolidine-2,4-dione
  • 3-bromo-5,5-dimethylimidazolidine-2,4-dione
  • 3-amino-5,5-dimethylimidazolidine-2,4-dione
  • 3-chloro-5,5-dimethylimidazolidine-2,4-dione
  • tert-butyl 2-[4-(2,2,2-trifluoroacetyl)-1H-pyrazol-1-yl]acetate
  • tert-butyl 2-[4-(piperidin-4-yl)-1H-pyrazol-1-yl]acetate
  • tert-butyl 2-[4-(3-aminoprop-1-yn-1-yl)-1H-pyrazol-1-yl]acetate
  • 2-chloro-1-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]ethan-1-one
  • 3-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]prop-2-yn-1-amine
  • 3-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]propanoic acid
  • 3-(4-ethynyl-1H-pyrazol-1-yl)propanenitrile
  • (2E)-3-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]prop-2-enoic acid
  • 3-[4-(2-aminoethyl)-1H-pyrazol-1-yl]propanenitrile
  • 3-(4-ethenyl-1H-pyrazol-1-yl)propanenitrile
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