Tributyl citrate

Suppliers

Names

[ CAS No. ]:
77-94-1

[ Name ]:
Tributyl citrate

[Synonym ]:
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tributyl ester
Tri-n-butyl citrate
Citric acid tri-n-butyl ester
EINECS 201-071-2
MFCD00027217
Citric acid, tributyl ester (8CI)
Tributyl citrate
tributyl 2-hydroxypropane-1,2,3-tricarboxylate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
389.8±9.0 °C at 760 mmHg

[ Melting Point ]:
≥300 °C(lit.)

[ Molecular Formula ]:
C₁₈H₃₂O₇

[ Molecular Weight ]:
360.45

[ Flash Point ]:
120.7±12.2 °C

[ Exact Mass ]:
360.214813

[ PSA ]:
99.13000

[ LogP ]:
4.68

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.465

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ8608000

CHEMICAL NAME :: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tributyl ester

CAS REGISTRY NUMBER :: 77-94-1

BEILSTEIN REFERENCE NO. :: 1806072

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C18-H32-O7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Vascular - other changes

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8120 mg/kg/14D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S26-S36/37/39-S45-S24/25

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
TZ8608000

[ HS Code ]:
2918150000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918150000

[ Summary ]:
2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%

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Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Thei...

Improved mechanical property and water resistance of zein films by plasticization with tributyl citrate.

J. Agric. Food Chem. 60(23) , 5988-93, (2012)

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Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion.

Eur. J. Pharm. Biopharm. 79(3) , 635-45, (2011)

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