SR 57227 hydrochloride

[ Boiling Point ]:
367.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₅Cl₂N₃

[ Molecular Weight ]:
248.15200

[ Flash Point ]:
176.1ºC

[ Exact Mass ]:
247.06400

[ PSA ]:
42.15000

[ LogP ]:
3.22980

Click to get detail MSDS

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R25;R36/37/38

[ Safety Phrases ]:
S26;S45

[ RIDADR ]:
UN2811 6.1/PG 3

[ RTECS ]:
TM3465250

The pyramidal neurons in the medial prefrontal cortex show decreased response to 5-hydroxytryptamine-3 receptor stimulation in a rodent model of Parkinson's disease.

Brain Res. 1384 , 69-79, (2011)

In the present study, effect of SR 57227A, a selective 5-hydroxytryptamine-3 (5-HT(3)) receptor agonist, on the firing activity of pyramidal neurons in the medial prefrontal cortex (mPFC) was studied ...

Discriminative stimulus effects of 5.6 mg/kg pregnanolone in DBA/2J and C57BL/6J inbred mice.

Alcohol 37(1) , 35-45, (2005)

Neurosteroids represent a class of endogenous compounds that exert rapid, nongenomic effects through neurotransmitter receptor systems such as gamma-aminobutyric acid(A) (GABA(A)). Two neurosteroids, ...

SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo.

Eur. J. Pharmacol. 237 , 299, (1993)

SR 57227A (4-amino-(6-chloro-2-pyridyl)-1 piperidine hydrochloride) is a novel compound with high affinity and selectivity for the 5-HT3 receptor. The compound had affinities (IC50) varying between 2....

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