ethyl 2-[(2-morpholin-4-ylacetyl)amino]-4-phenyl-thiophene-3-carboxylate

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Names

[ CAS No. ]:
77261-23-5

[ Name ]:
ethyl 2-[(2-morpholin-4-ylacetyl)amino]-4-phenyl-thiophene-3-carboxylate

[Synonym ]:
ETHYL 2-[(2-MORPHOLIN-4-YLACETYL)AMINO]-4-PHENYL-THIOPHENE-3-CARBOXYLATE
3-Thiophenecarboxylic acid,2-((4-morpholinylacetyl)amino)-4-phenyl-,ethyl ester
ethyl 2-[(morpholin-4-ylacetyl)amino]-4-phenylthiophene-3-carboxylate
Ethyl 2-((4-morpholinylacetyl)amino)-4-phenyl-3-thiophenecarboxylate

Chemical & Physical Properties

[ Density]:
1.263g/cm3

[ Boiling Point ]:
568.7ºC at 760 mmHg

[ Molecular Formula ]:
C19H22N2O4S

[ Molecular Weight ]:
374.45400

[ Flash Point ]:
297.7ºC

[ Exact Mass ]:
374.13000

[ PSA ]:
96.11000

[ LogP ]:
2.87340

[ Index of Refraction ]:
1.601

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XM8511050
CHEMICAL NAME :
3-Thiophenecarboxylic acid, 2-((4-morpholinylacetyl)amino)-4-phenyl-, ethyl ester
CAS REGISTRY NUMBER :
77261-23-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C19-H22-N2-O4-S
MOLECULAR WEIGHT :
374.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 15,563,1980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Acetophenone
  • Ethyl cyanoacetate
  • morpholine
  • 2-(2-CHLORO-ACETYLAMINO)-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
  • Ethyl 2-amino-4-phenyl-3-thiophenecarboxylate

DownStream

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 4-(1-Ethylcyclopropyl)-8-oxa-1-azaspiro[4.5]decan-2-one
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide