1,3-Dichloroisoquinoline

Names

[ CAS No. ]:
7742-73-6

[ Name ]:
1,3-Dichloroisoquinoline

[Synonym ]:
1,3-Dichloroisoquinoline
Isoquinoline, 1,3-dichloro-
MFCD00034750
1,3-Dichloroisoquinoline acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
328.7±22.0 °C at 760 mmHg

[ Melting Point ]:
121-122 °C(lit.)

[ Molecular Formula ]:
C₉H₅Cl₂N

[ Molecular Weight ]:
198.05

[ Flash Point ]:
182.6±7.9 °C

[ Exact Mass ]:
196.979904

[ PSA ]:
12.89000

[ LogP ]:
3.31

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.661

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Isoquinoline-1,3(2H,4H)-dione
o-Carboxyphenylacetonitrile
phenylphosphonicdichlorid
1 (2H)-Isoquinolinone, 3-hydroxy-
2-Furanboronic acid
Homophthalic acid
2-phenethyl-4H-isoquinoline-1,3-dione
phosphoryl trichloride

DownStream

Isoquinoline
1,2,3,4-Tetrahydroisoquinoline
TERT-BUTYL 4-(ISOQUINOLIN-1-YL)PIPERAZINE-1-CARBOXYLATE
3-Chloroisoquinolin-5-amine
3-Chloro-5-nitroisoquinoline
1-Piperazine-1-yl-isoquinoline
3-Chloro-1-methoxyisoquinoline
3-Chloroisoquinoline
3-chloroisoquinolin-1-amine
1 (2H)-Isoquinolinone, 3-hydroxy-

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthetic antimalarials; some derivatives of phthalazine, quinoxaline, and isoquinoline.

J. Chem. Soc. 174 , 777-82, (1948)

Exploitation of differential reactivity of the carbon–chlorine bonds in 1, 3-dichloroisoquinoline. Routes to new N, N-chelate ligands and 1, 3-disubstituted isoquinolines. Ford A, et al.

J. Chem. Soc. Perkin Trans. I 6 , 927-34, (1997)

A facile synthesis of 1, 3, 4-trisubstituted isoquinolines. Yang H.

Tetrahedron Lett. 50(25) , 3081-83, (2009)

5-bromo-1,3-dichloroisoquinoline
7-Bromo-1,3-dichloroisoquinoline
4-AMINO-1,3-DICHLOROISOQUINOLINE
6-Bromo-1,3-dichloroisoquinoline
8-Bromo-1,3-dichloroisoquinoline
7-Methyl-1,3-dichloroisoquinoline
4-Cyano-5-ethyl-2-(trifluoromethyl)benzenesulfonyl chloride
1-(3-Ethoxy-5-ethylphenyl)propan-2-one
1,5-Diiodo-2-ethyl-3-fluorobenzene
4-(Difluoromethyl)-5-hydroxy-2-nitronicotinamide
4-(Difluoromethyl)-5-fluoro-3-methoxypyridine-2-sulfonyl chloride
1-(3-Iodo-4-methylphenyl)propan-2-one
2-(Aminomethyl)-3-(difluoromethyl)-4-methylpyridine-5-acetonitrile
2-(Difluoromethyl)-4-(3-oxopropyl)cinnamic acid
2-(Difluoromethyl)-5-hydroxy-3-iodopyridine-4-sulfonyl chloride
4-Bromo-2-(difluoromethoxy)-3-fluoropyridine

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