3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
Suppliers
Names
[ CAS No. ]:
77439-76-0
[ Name ]:
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
[Synonym ]:
Mutagen X
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, (MX)
3-Chloro-4-(dichloromethyl)-5-hydroxyfuran-2(5H)-one
3-chloro-4-dichloromethyl-5-hydroxy-2<H>-furanone
2(5H)-Furanone, 3-chloro-4-(dichloromethyl)-5-hydroxy-
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
Mx
Chemical & Physical Properties
[ Density]:
1.8±0.1 g/cm3
[ Boiling Point ]:
388.7±42.0 °C at 760 mmHg
[ Molecular Formula ]:
C5H3Cl3O3
[ Molecular Weight ]:
217.434
[ Flash Point ]:
188.9±27.9 °C
[ Exact Mass ]:
215.914780
[ PSA ]:
46.53000
[ LogP ]:
0.06
[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C
[ Index of Refraction ]:
1.572
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LU3482000
- CHEMICAL NAME :
- 2(5H)-Furanone, 3-chloro-4-dichloromethyl-5-hydroxy-
- CAS REGISTRY NUMBER :
- 77439-76-0
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 33
- MOLECULAR FORMULA :
- C5-H3-Cl3-O3
- MOLECULAR WEIGHT :
- 217.43
- WISWESSER LINE NOTATION :
- T5OVJ CG DYGG EQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 256 mg/kg/4D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Metabolism (Intermediary) - xanthine, purine or nucleotides including urate
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4050 mg/kg/14W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg/14D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in leukocyte (WBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2700 mg/kg/18W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- DNA damage
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 2 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 310,117,1994
Safety Information
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
R46
[ Safety Phrases ]:
53-36/37/39-45
[ RIDADR ]:
UN 2810
[ RTECS ]:
LU3482000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
[ HS Code ]:
2932209090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932209090
[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%