(2R,4S)-tert-Butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

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Names

[ CAS No. ]:
77450-03-4

[ Name ]:
(2R,4S)-tert-Butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

[Synonym ]:
(2R,4S)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
(2R,4S)-N-Boc-4-hydroxyprolinol
(2R,4S)-4-Hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
2-Methyl-2-propanyl (2R,4S)-4-hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylate
N-(tert-Butoxycarbonyl)-4-hydroxy-D-prolinol
trans-4-Hydroxy-L-prolinol,N-BOC protected
N-(tert-butoxycarbonyl)-trans-4-hydroxy-D-prolinol
(2S,4R)-tert-butyl4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
(2R,4S)-4-hydroxyprolinol-1-carboxylic acid tert-butyl ester

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
340.3±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H19NO4

[ Molecular Weight ]:
217.262

[ Flash Point ]:
159.6±23.7 °C

[ Exact Mass ]:
217.131409

[ PSA ]:
70.00000

[ LogP ]:
-0.83

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.511

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Boc-trans-D-Hyp-OMe
  • (2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester
  • N-(tert-butoxycarbonyl)-trans-4-acetoxy-D-proline methyl ester
  • N-(tert-butoxycarbonyl)-trans-4-formyloxy-D-proline ethyl ester
  • N-(tert-butoxycarbonyl)-trans-4-hydroxy-D-proline ethyl ester
  • Di-tert-butyl dicarbonate
  • (4R)-4-Hydroxy-D-proline hydrochloride (1:1)
  • L-Hydroxyproline
  • N-Boc-cis-4-Hydroxy-D-proline
  • N-Boc-cis-4-hydroxy-D-proline methyl ester

DownStream

  • [(2R,4R)-4-(2,6-diaminopurin-9-yl)pyrrolidin-2-yl]methanol
  • (2R,4R)-BPPM

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%