1-Benzyl-3-pyrrolidinol

Names

[ CAS No. ]:
775-15-5

[ Name ]:
1-Benzyl-3-pyrrolidinol

[Synonym ]:
1-benzylpyrrolidin-3-ol
1-benzyl-3-hydroxypyrrolidine
3-Pyrrolidinol, 1-(phenylmethyl)-
MFCD00012132
EINECS 212-273-5
1-Benzyl-3-pyrrolidinol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
297.8±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₅NO

[ Molecular Weight ]:
177.243

[ Flash Point ]:
115.7±18.1 °C

[ Exact Mass ]:
177.115356

[ PSA ]:
23.47000

[ LogP ]:
0.80

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.596

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 2810

[ WGK Germany ]:
1

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

1-Tosyl-3-pyrrolidinol
3-Pyrrolidinol, 1-(phenylmethyl)-, 4-Methylbenzenesulfonate (ester)
1-Benzyl-3-pyrrolidinone
BUTANOIC ACID,3-OXO-,(3S)-1-(PHENYLMETHYL)-3-PYRROLIDINYL ESTER
Barnidipine
Barnidipine
(S)-1-Benzyl-3-[(p-tolylsulfonyl)oxy]pyrrolidine
(3S)-1-Benzyl-3-methylpyrrolidine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

J. Med. Chem. 29(12) , 2504-11, (1986)

Four enantiomers (3a-d) of the title compound, YM-09730 (3), were synthesized by the reaction of (-)- or (+)-5-(methoxycarbonyl)-2, 6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (...

Efficient synthesis of the 5-HT2c receptor agonist, Org 37684. Adams DR and Duncton MAJ.

Synth. Commun. 31(13) , 2029-36, (2001)