MeIQx

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Names

[ Name ]:
MeIQx

[Synonym ]:
3,8-dimethyl-3H-imidazo<quinoxalin-2-amine
3,8-dimethylimidazo[4,5-f]quinoxalin-2-amine
8-MeIQX
8-Methyl-IQX

Chemical & Physical Properties

[ Density]:
1.47 g/cm3

[ Boiling Point ]:
458.4ºC at 760mmHg

[ Melting Point ]:
> 300ºC

[ Molecular Formula ]:
C₁₁H₁₁N₅

[ Molecular Weight ]:
213.23900

[ Exact Mass ]:
213.10100

[ PSA ]:
69.62000

[ LogP ]:
1.98830

[ Index of Refraction ]:
1.776

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ5925500

CHEMICAL NAME :: 3H-Imidazo(4,5-f)quinoxaline, 2-amino-3,8-dimethyl-

CAS REGISTRY NUMBER :: 77500-04-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 27

MOLECULAR FORMULA :: C11-H11-N5

MOLECULAR WEIGHT :: 213.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8580 mg/kg/61W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42336 mg/kg/84W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - leukemia

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,91,1983 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,211,1993 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,283,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,283,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,211,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,211,1993

Safety Information

[ Hazard Codes ]:
T

[ RTECS ]:
NJ5925500

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

MeIQx-d3
Di-meIQX
MeIQx-14C
8-PH-5-MEIQX
7-PH-5-MEIQX
N-Acetoxy-meiqx
8-[(1R)-2-[(1,1-Dimethylethyl)(4-methoxyphenyl)amino]-1-hydroxyethyl]-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one
4-Pyridinecarboxylic acid, 2-[4-[[[1-(2-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-1-piperidinyl]-
Methyl 4-[1,5,6,7,8,9-hexahydro-7-(2,2,2-trifluoroacetyl)imidazo[4,5-h][3]benzazepin-2-yl]-1-piperidinecarboxylate
1-Piperazinecarboxylic acid, 4-[4-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]pentyl]-, 1,1-dimethylethyl ester
9,12,15-Octadecatrienoic acid, 17-[(2-O-I(2)-D-glucopyranosyl-I(2)-D-glucopyranosyl)oxy]-, intramol. 1,6a(2)a(2)-ester, (17S)-
3-Oxazolidinecarboxylic acid, 4-(3-ethoxy-2-methyl-3-oxo-1-propenyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (R)-
1,5-Methano-2H-pyrido[1,2-a][1,5]diazocine-3(4H)-carboxamide, 1,5,6,8-tetrahydro-N-(4-nitrophenyl)-8-oxo-, (1R)-
4-[2-(5-Amino-2-sulfophenyl)diazenyl]-4,5-dihydro-1-(2-methyl-4-sulfophenyl)-5-oxo-1H-pyrazole-3-carboxylic acid
(2S)-1-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid
Cinchonan-9-ol, 11-[(2-aminoethyl)thio]-10,11-dihydro-6a(2)-methoxy-, 9-[N-(1,1-dimethylethyl)carbamate], (8I+/-,9R)-

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