Sodium chlorite

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Names

[ CAS No. ]:
7758-19-2

[ Name ]:
Sodium chlorite

[Synonym ]:
EINECS 231-836-6
Chlorite (sodium salt)
MFCD01732064
Sodium chlorite
sodium,chlorite

Chemical & Physical Properties

[ Density]:
1.28 g/cm3 (20ºC)

[ Boiling Point ]:
112ºC

[ Melting Point ]:
190 °C (dec.)

[ Molecular Formula ]:
ClNaO2

[ Molecular Weight ]:
90.442

[ Exact Mass ]:
89.948456

[ PSA ]:
40.13000

[ LogP ]:
0.45190

[ Stability ]:
Stable. Incompatible with phosphorus, sulphur, zinc, ammonia, finely powdered metals, strong reducing agents, acids, organic materials.

[ Water Solubility ]:
39 g/100 mL (17 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VZ4800000
CHEMICAL NAME :
Sodium chlorite
CAS REGISTRY NUMBER :
7758-19-2
LAST UPDATED :
199806
DATA ITEMS CITED :
28
MOLECULAR FORMULA :
Cl-H-O2.Na
MOLECULAR WEIGHT :
91.45
WISWESSER LINE NOTATION :
.NA..G-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
165 mg/kg
TOXIC EFFECTS :
Liver - jaundice, other or unclassified Kidney, Ureter, Bladder - interstitial nephritis Biochemical - Metabolism (Intermediary) - other
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
230 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
365 mg/kg/1Y-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in other cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
182 gm/kg/26W-I
TOXIC EFFECTS :
Liver - liver function tests impaired Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
29750 mg/kg/85W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
800 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
16 gm/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
660 mg/kg
SEX/DURATION :
male 66 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1130 mg/kg
SEX/DURATION :
male 8 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
160 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
80 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22 gm/kg
SEX/DURATION :
female 1-21 day(s) after conception lactating female 28 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Sperm Morphology
TYPE OF TEST :
Micronucleus test

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
20 mg/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,145,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,145,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,145,1991 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81982 No. of Facilities: 129 (estimated) No. of Industries: 8 No. of Occupations: 13 No. of Employees: 1968 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81982 No. of Facilities: 532 (estimated) No. of Industries: 20 No. of Occupations: 27 No. of Employees: 18585 (estimated) No. of Female Employees: 4817 (estimated)

Safety Information

[ Symbol ]:

GHS03, GHS05, GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H271-H301-H310-H314-H373-H410

[ Supplemental HS ]:
Contact with acids liberates very toxic gas., Corrosive to the respiratory tract.

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P210-P280-P303 + P361 + P353-P305 + P351 + P338-P370 + P378

[ Target Organs ]:
spleen

[ Hazard Codes ]:
O:Oxidizingagent;T+:Verytoxic;

[ Risk Phrases ]:
R25;R26;R32;R34;R9

[ Safety Phrases ]:
S17-S26-S36/37/39-S45-S50A-S38-S36

[ RIDADR ]:
UN 2813 4.3/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
VZ4800000

[ Packaging Group ]:
II

[ Hazard Class ]:
5.1

[ HS Code ]:
2828900000

Synthetic Route

Precursor & DownStream

Precursor

  • Chlorine dioxide
  • sodium sulfate
  • SodiuM bicarbonate
  • iodine(•)
  • sodium nitrate
  • Barium peroxide
  • sodium chloride
  • Sodium hypochlorite

DownStream

  • 2-Chloro-1H-indole-3-carboxylic acid
  • 1H-Indole-3-carbonyl chloride, 2-chloro- (9CI)
  • sodium chloride
  • L-Dehydroascorbic acid
  • MK-0752
  • 4-Iodoaniline
  • 2,2′-Dipyridyl disulfide
  • Chlorine dioxide
  • Carbon dioxide
  • chlorate

Customs

[ HS Code ]: 2828900000

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Related Compounds

  • Sodium chlorite trihydrate
  • sodium,(Z)-4-[(2-amino-3-methylbutanoyl)amino]-3-chloro-5-hydroxy-5-oxopent-2-enoate
  • sodium lauroamphoacetate
  • sodium boron(-1) anion
  • Sodium isethionate
  • sodium,3-[dimethylamino(methylcarbamothioyl)amino]propanoate
  • Methyl 1-(2-chloroacetamido)-4-methyl-1,2,3,4-tetrahydronaphthalene-1-carboxylate
  • (2E)-N-(2-carbamoylethyl)-N-(3,4-dihydro-2H-1-benzopyran-4-yl)-4-(dimethylamino)but-2-enamide
  • N-[3-(2-fluorophenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-6-yl]prop-2-enamide
  • N-{[5-(1,1,2,2,2-pentafluoroethyl)-1,2-oxazol-3-yl]methyl}but-2-ynamide
  • N-(2-{1-[(4-chlorophenyl)methyl]-1H-imidazol-4-yl}ethyl)but-2-ynamide
  • (2E)-N-[1-(5-chloropyridin-2-yl)-2-cyclopropylethyl]-4-(dimethylamino)but-2-enamide
  • N-[1-(4-cyanophenyl)-3-methyl-1H-1,2,4-triazol-5-yl]-2-phenylethene-1-sulfonamide
  • 3-(bromomethyl)-1-(trifluoromethyl)-1H-pyrazole
  • (2E)-N-[1-(4-chlorophenyl)-2,2,2-trifluoroethyl]-4-(dimethylamino)-N-methylbut-2-enamide
  • 1-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperazin-1-yl]prop-2-en-1-one
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