Nestoron

Suppliers

Names

[ Name ]:
Nestoron

[Synonym ]:
NESTORONE
19-Norpregn-4-ene-3,20-dione,17-hydroxy-16-methylene-,acetate
16-Methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione acetate
17-(ACETYLOXY)-16-METHYLENE-19-NORPREGN-4-ENE-20-DIONE
17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate
Elcometrine

Chemical & Physical Properties

[ Density]:
1.15g/cm3

[ Boiling Point ]:
499.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₃H₃₀O₄

[ Molecular Weight ]:
370.48200

[ Flash Point ]:
216.2ºC

[ Exact Mass ]:
370.21400

[ PSA ]:
60.44000

[ LogP ]:
4.18520

[ Index of Refraction ]:
1.549

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC8960750

CHEMICAL NAME :: 19-Norpregn-4-ene-3,20-dione, 17-hydroxy-16-methylene-, acetate

CAS REGISTRY NUMBER :: 7759-35-5

LAST UPDATED :: 199306

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C23-H30-O4

MOLECULAR WEIGHT :: 370.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 240 ug/kg

SEX/DURATION :: female 24 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 58,680,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 800 ug/kg

SEX/DURATION :: female 56 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 25,299,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 2200 ug/kg

SEX/DURATION :: female 43 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 18,411,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 700 ug/kg

SEX/DURATION :: female 26 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 36,737,1981

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Nestorone: clinical applications for contraception and HRT.

Steroids 68(10-13) , 907-13, (2003)

The 19-nor derivatives of progesterone are referred to as "pure" progestational molecules as they bind almost exclusively to the progesterone receptor (PR) without interfering with receptors of other ...

Recent developments in contraceptive implants at the Population Council.

Contraception 65(1) , 113-9, (2002)

Development of contraceptive implant methods, when based on established or on new synthetic chemical entities, is a decadal or multi-decadal process. The process often requires the cooperation of nume...

Central modifications of allopregnanolone and beta-endorphin following subcutaneous administration of Nestorone.

J. Steroid Biochem. Mol. Biol. 116(1-2) , 15-20, (2009)

The aim of the present study was to evaluate the potential action of Nestorone (alone or in combination with estradiol valerate) on the level of allopregnanolone and of the opioid beta-endorphin in se...