D-Ribitol,1-C-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-1,4-anhydro-, (1S)-

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Names

[ CAS No. ]:
77691-03-3

[ Name ]:
D-Ribitol,1-C-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-1,4-anhydro-, (1S)-

[Synonym ]:
9-deazaadenosine

Chemical & Physical Properties

[ Density]:
1.688g/cm3

[ Boiling Point ]:
684.8ºC at 760 mmHg

[ Molecular Formula ]:
C11H15ClN4O4

[ Molecular Weight ]:
302.71400

[ Flash Point ]:
368ºC

[ Exact Mass ]:
302.07800

[ PSA ]:
137.51000

[ LogP ]:
0.07730

[ Index of Refraction ]:
1.787

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY8860000
CHEMICAL NAME :
7H-Pyrrolo(3,2-d)pyrimidine, 4-amino-7-beta-D-arabinofuranosyl-
CAS REGISTRY NUMBER :
77691-03-3
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C11-H14-N4-O4
MOLECULAR WEIGHT :
266.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
10 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,306,1983

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Formyl-2-(2,3-O-isopropyliden-5-O-trityl-D-ribofuranosyl)acetonitril
  • 3-((cyanomethyl)amino)-2-((3aS,6R,6aR)-2,2-dimethyl-6-((trityloxy)methyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)acrylonitrile
  • ethyl 3-amino-2-cyano-4-((3aS,6R,6aR)-2,2-dimethyl-6-((trityloxy)methyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-1-carboxylate
  • 2-((3aS,6R,6aR)-2,2-dimethyl-6-((trityloxy)methyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-3-(dimethylamino)acrylonitrile
  • 3-amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-((trityloxy)methyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile
  • 7-((3aS,6R,6aR)-2,2-dimethyl-6-((trityloxy)methyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

DownStream

Related Compounds

  • 1h-Indole-3-acetonitrile,7-acetyl-
  • (R)-1-(4,5-Dihydrofuran-3-yl)-2,2,2-trifluoroethan-1-amine
  • (1R)-2,2,2-Trifluoro-1-naphthylethylamine
  • (S)-2-Amino-3-(4-methoxy-phenyl)-2-methyl-propionic acid ethyl ester
  • N-(3,4-dimethoxyphenyl)-2-((3-(thiophen-2-yl)-1,4-diazaspiro[4.5]deca-1,3-dien-2-yl)thio)acetamide
  • N-(3-chloro-2-methylphenyl)-2-((3-(thiophen-2-yl)-1,4-diazaspiro[4.5]deca-1,3-dien-2-yl)thio)acetamide
  • N-(2,5-difluorophenyl)-2-((3-(thiophen-2-yl)-1,4-diazaspiro[4.6]undeca-1,3-dien-2-yl)thio)acetamide
  • N-(3,4-difluorophenyl)-2-((3-(thiophen-2-yl)-1,4-diazaspiro[4.5]deca-1,3-dien-2-yl)thio)acetamide
  • Thieno[3,2-c]pyridine-5(4H)-butanamide, 6,7-dihydro-gamma-oxo-N-[4-(2-phenyldiazenyl)phenyl]-
  • N-(4-methoxyphenyl)-2-((3-(thiophen-2-yl)-1,4-diazaspiro[4.5]deca-1,3-dien-2-yl)thio)acetamide
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