beryllium sulfate tetrahydrate

Names

[ CAS No. ]:
7787-56-6

[ Name ]:
beryllium sulfate tetrahydrate

[Synonym ]:
MFCD00149156
EINECS 236-842-2
BERYLLIUM SULFATE TETRAHYDRATE

Chemical & Physical Properties

[ Density]:
1.713 g/mL at 25 °C(lit.)

[ Boiling Point ]:
330ºC at 760 mmHg

[ Melting Point ]:
270ºC

[ Molecular Formula ]:
BeH₈O₈S

[ Molecular Weight ]:
177.13600

[ Exact Mass ]:
177.00600

[ PSA ]:
125.56000

[ Stability ]:
Stable.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DS5000000

CAS REGISTRY NUMBER :: 7787-56-6

LAST UPDATED :: 199712

DATA ITEMS CITED :: 56

MOLECULAR FORMULA :: O4-S.Be.4H2-O

MOLECULAR WEIGHT :: 177.15

WISWESSER LINE NOTATION :: BE S-O4 &QH 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3850 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4971 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - fluid intake Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 470 ug/kg

TOXIC EFFECTS :: Behavioral - fluid intake Skin and Appendages - hair

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/m3/6H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/m3/6H/2W-I

TOXIC EFFECTS :: Behavioral - irritability Liver - other changes Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 90 mg/m3/6H/2W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Blood - changes in leukocyte (WBC) count Skin and Appendages - dermatitis, irritative (after systemic exposure)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 90 mg/m3/6H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 90 mg/m3/6H/2W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - conjunctive irritation

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 90 mg/m3/6H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 668 ug/m3/40W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Embryo

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,597,1981 *** REVIEWS *** ACGIH TLV-SUSPECTED HUMAN CARCINOGEN 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997 ACGIH TLV-TWA 0.002 mg(Be)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,17,1972 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,143,1980 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 58,41,1993 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 58,41,1993 IARC Cancer Review:Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 58,41,1993 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.001 mg(Be)/m3;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.002 mg(Be)/m3;STEL 0.006 mg(Be)/m3;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-JAPAN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-POLAND:TWA 0.001 mg(Be)/m3 JAN 1993 OEL-RUSSIA:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993 OEL-SWEDEN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 0.002 mg(Be)/m3;STEL 0.005 mg(Be)/m3 JAN 1993 OEL-TURKEY:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.002 mg(Be)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BERYLLIUM-air:CA not to exceed 0.0005 mg(Be)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6326 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1822 (estimated) No. of Female Employees: 230 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H317-H319-H330-H335-H350i-H372-H411

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P201-P260-P280-P304 + P340 + P310-P308 + P313

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+,N

[ Risk Phrases ]:
R49

[ Safety Phrases ]:
S53-S45-S61

[ RIDADR ]:
UN 1566 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
DS5000000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

Articles

[Diagnosis of chronic berylliosis].

Pneumologie 53(4) , 193-8, (1999)

The diagnostic value of the lymphocyte transformation test (BeLT) and the intracutaneous skin test with berylliumsulfate was addressed in 13 patients with chronic berylliosis, and 15 individuals with ...

Beryllium-stimulated release of tumor necrosis factor-alpha, interleukin-6, and their soluble receptors in chronic beryllium disease.

Am. J. Respir. Crit. Care Med. 156(6) , 1884-91, (1997)

Chronic beryllium disease (CBD) provides a model system in which to evaluate the antigen-stimulated, cell-mediated, immune response that leads to granulomatous lung disease. We hypothesized that beryl...

Target organ localization of memory CD4(+) T cells in patients with chronic beryllium disease.

J. Clin. Invest. 110(10) , 1473-82, (2002)

Chronic beryllium disease (CBD) is caused by exposure to beryllium in the workplace, and it remains an important public health concern. Evidence suggests that CD4(+) T cells play a critical role in th...

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