Gilvocarcin V

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Names

[ CAS No. ]:
77879-90-4

[ Name ]:
Gilvocarcin V

[Synonym ]:
Gilvocacin V
1,4-Anhydro-6-deoxy-1-(1-hydroxy-10,12-dimethoxy-6-oxo-8-vinyl-6H-dibenzo[c,h]chromen-4-yl)hexitol
Hexitol, 1,4-anhydro-6-deoxy-1-C-(8-ethenyl-1-hydroxy-10,12-dimethoxy-6-oxo-6H-benzo[d]naphtho[1,2-b]pyran-4-yl)-
gilvocarcin V

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
821.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H26O9

[ Molecular Weight ]:
494.490

[ Flash Point ]:
280.1±27.8 °C

[ Exact Mass ]:
494.157684

[ PSA ]:
138.82000

[ LogP ]:
4.00

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.698

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DI2240000
CHEMICAL NAME :
6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosyl)-8-ethenyl- 1-hydroxy-10,12-dimethoxy-
CAS REGISTRY NUMBER :
77879-90-4
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C27-H26-O9
MOLECULAR WEIGHT :
494.53
WISWESSER LINE NOTATION :
T E6 B666 COVJ G1U1 IO1 MO1 OQ R- BT5OTJ CQ DQ EYQ1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
500 ug/L
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 35,545,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Gilvocarcin V

DownStream

  • 4-β-fucofuranosyl-1-hydroxy-10,12-dimethoxy-8-vinyl-6H-benzo(d)-naphtho(1,2-b) pyran-6-one
  • Gilvocarcin V

Related Compounds

  • gilvocarcin V
  • defucogilvocarcin V
  • gilvocarcin E
  • Gilvocarcin M
  • manganese(V) chloride
  • trinitratooxovanadium(V)
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(5-methyl-1,2-oxazol-3-yl)-2-[[1-(3-methylphenyl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]acetamide
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • N-((3-(2-hydroxyethoxy)tetrahydrofuran-3-yl)methyl)-1H-indole-2-carboxamide
  • tert-Butyl-DL-alanine