3-(Trifluoromethyl)cinnamic acid

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Names

[ CAS No. ]:
779-89-5

[ Name ]:
3-(Trifluoromethyl)cinnamic acid

[Synonym ]:
MFCD00004393
3-rifluoromethyl)CinnamicAcid
EINECS 212-301-6
2-Propenoic acid, 3-[3-(trifluoromethyl)phenyl]-
m-Trifluoromethyl cinnamic acid
3-[3-(Trifluoromethyl)phenyl]acrylic acid
RARECHEM BK HW 0018
MTF-CNA
3-(3-(Trifluoromethyl)phenyl)acrylic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
289.6±35.0 °C at 760 mmHg

[ Melting Point ]:
135-137 °C(lit.)

[ Molecular Formula ]:
C10H7F3O2

[ Molecular Weight ]:
216.157

[ Flash Point ]:
129.0±25.9 °C

[ Exact Mass ]:
216.039810

[ PSA ]:
37.30000

[ LogP ]:
3.27

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.526

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R37/38

[ Safety Phrases ]:
S26-S37/39-S37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • m-iodobenzotrifluoride
  • acrylic acid methyl ester
  • Malonic acid
  • 3-(Trifluoromethyl)benzaldehyde
  • Ethanoic anhydride

DownStream

  • 3-(3-Trifluoromethylphenyl)propionic acid
  • 3-(Trifluoromethyl)benzaldehyde
  • 3-(3'-Trifluoromethylphenyl)propanol
  • Cinacalcet metabolite M4
  • Cinacalcet hydrochloride
  • 1-(3-Bromopropyl)-3-(trifluoromethyl)benzene
  • Cinacalcet
  • (2E)-3-[3-(Trifluoromethyl)phenyl]acrylaldehyde
  • 3-(Trifluoromethyl)benzenepropanal
  • 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Practical synthesis of the calcimimetic agent, cinacalcet. Thiel OR, et al.

Tetrahedron Lett. 49(1) , 13-15, (2008)


More Articles

Related Compounds

  • (E)-3-(trifluoromethyl)cinnamic acid
  • 4-Fluoro-3-(trifluoromethyl)cinnamic acid
  • 2-FLUORO-3-(TRIFLUOROMETHYL)CINNAMIC ACID
  • 4-Chloro-3-(trifluoromethyl)cinnamic acid
  • 4-METHYL-3-(TRIFLUOROMETHYL)CINNAMIC ACID
  • 4-fluoro-3-(trifluoromethyl)cinnamic acid
  • (2R)-1-[(2S,3S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]-2-methylpyrrolidine-2-carboxylic acid
  • 5-(2,2,2-Trifluoroacetamido)-1,3-oxazole-4-carboxylic acid
  • 3-(2,2,2-Trifluoroacetamido)-1,2-oxazole-5-carboxylic acid
  • 2-(2,2,2-Trifluoroacetamido)-1,3-oxazole-4-carboxylic acid
  • (2S)-1-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoyl]-2-methylpyrrolidine-2-carboxylic acid
  • 2-[N-(2-cyanoethyl)-2,2,2-trifluoroacetamido]acetic acid
  • 3-(2-Carboxy-2-acetamidoethyl)pyridin-1-ium-1-olate
  • rac-(2R,4R)-1-acetyl-4-(1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylic acid
  • rac-ethyl (3R,4S)-3-amino-4-(1H-1,2,3-triazol-1-yl)cyclopentane-1-carboxylate
  • prop-2-en-1-yl (1R,3S,5S)-3-(aminomethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate
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