trifluorochlorine

MOLECULAR FORMULA :

Cl-F3

MOLECULAR WEIGHT :

92.45

WISWESSER LINE NOTATION :

G F3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rat

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 12,515,1955

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Mammal - dog

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 12,515,1955 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

50 ppm

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,651,1966

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

299 ppm/1H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,417,1977

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

178 ppm/1H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - cyanosis

REFERENCE :

AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433) Volume(issue)/page/year: TR-70-77,1970

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

230 ppm/1H

TOXIC EFFECTS :

Behavioral - muscle weakness Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - cyanosis

REFERENCE :

AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433) Volume(issue)/page/year: TR-70-77,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5150 ppb/6H/6W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - changes in structure or function of salivary glands Related to Chronic Data - death

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 12,515,1955

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1170 ppb/6H/26W-I

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - chronic pulmonary edema Related to Chronic Data - death

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,340,1956

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

5150 ppb/6H/6W-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - corneal damage Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Related to Chronic Data - death

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 12,515,1955

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

1170 ppb/6H/26W-I

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,340,1956 *** REVIEWS *** ACGIH TLV-CL 0.38 mg/m3 (0.1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,527,1974 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:air-CL 0.1 ppm (0.4 mg/m3) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,11,1972 OSHA PEL (Gen Indu):CL 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-BELGIUM:STEL 0.1 ppm (0.38 mg/m3) JAN 1993 OEL-DENMARK:STEL 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-FINLAND:STEL 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-FRANCE:STEL 0.4 mg/m3 JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.4 mg/m3);STEL 0.2 ppm (0.8 mg/m3) JAN 1993 OEL-THAILAND:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.4 mg/m3);STEL 0.1 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLORINE TRIFLUORIDE-air:CL 0.1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18050 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 357 (estimated)