Sulfuryl chloride

Names

[ Name ]:
Sulfuryl chloride

[Synonym ]:
Sulfuryl chloride
Sulphuryl dichloride
Sulfuryl dichloride
Sulphuryl chloride
EINECS 232-245-6
MFCD00011451
sulfonyl chloride

Chemical & Physical Properties

[ Density]:
1.667

[ Boiling Point ]:
69 ºC

[ Melting Point ]:
-54.1 °C

[ Molecular Formula ]:
Cl₂O₂S

[ Molecular Weight ]:
134.970

[ Flash Point ]:
69.1°C

[ Exact Mass ]:
133.899612

[ PSA ]:
42.52000

[ LogP ]:
1.24

[ Vapour density ]:
4.7 (vs air)

[ Vapour Pressure ]:
147.7±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.479

[ Stability ]:
Reacts violently with water. Incompatible with acids, alcohols, bases, metals, amines, moisture.

[ Water Solubility ]:
reacts

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WT4870000

CHEMICAL NAME :: Sulfuryl chloride

CAS REGISTRY NUMBER :: 7791-25-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: Cl2-O2-S

MOLECULAR WEIGHT :: 134.96

WISWESSER LINE NOTATION :: S O2-G2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 159 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,62,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 ppm/6H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - changes in lung weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,62,1983 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2850 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(7),9,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4088 No. of Facilities: 33 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2256 (estimated) No. of Female Employees: 657 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H335

[ Supplemental HS ]:
Reacts violently with water.

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Target Organs ]:
Blood, Central nervous system, Liver

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R14;R34;R40

[ Safety Phrases ]:
S26-S45-S36/37-S36/37/39

[ RIDADR ]:
UN 2927 6.1/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
WT4870000

[ Packaging Group ]:
I

[ Hazard Class ]:
8

[ HS Code ]:
2812101000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Chlorosulfonic acid
pyrosulfuryl chloride
SULFUR DIOXIDE
Chlorine
Disulfur dichloride
Thionyl chloride
Sulfur dichloride
Aluminium chloride
Sulfur trioxide
Boron trichloride

DownStream

Stannane, dichlorobis[(chlorosulfonyl)oxy]
1,2,3,4-tetrachloro-5-methylbenzene
1-Hexadecanesulfonylchloride
1,2,2-trichloropropane
1,1,2-TRICHLOROPROPANE
1,2,3-Trichloropropane
Ethyl 4-chlorobutanoate
Ethyl-2-chloro-n-butanoate
Ethyl-3-chloro-n-butanoate
METHYL 2-CHLOROBUTYRATE

Customs

[ HS Code ]: 2812101000

Articles

Trichlorophenol (TCP) sulfonate esters: a selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides.

Chem. Commun. (Camb.) (10) , 1074-6, (2007)

2,4,6-Trichlorophenol (TCP) sulfonate esters undergo effective aminolysis under conventional heating and microwave irradiation; the reactivity of these species is such that chemoselective transformati...

Detection of Infertility-related Neutralizing Antibodies with a Cell-free Microfluidic Method.

Sci. Rep. 5 , 16551, (2015)

The unwanted emergence of neutralizing antibodies (nAbs) against an endogenous or a therapeutic protein can result in deficiency diseases or therapy failure. Here, we developed a cell-free microfluidi...

pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence.

ACS Nano 9(3) , 2390-404, (2015)

Development of effective therapies to control oral biofilms is challenging, as topically introduced agents must avoid rapid clearance from biofilm-tooth interfaces while targeting biofilm microenviron...

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sulfuryl dibromide
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2-(1H-indazol-3-yl)-2-methylpropan-1-ol
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4-Methyl-4-[2-(methylsulfanyl)phenoxy]piperidine
4-[1-(2,3-Dimethylphenyl)ethyl]piperidine
2-Hydroxy-2-[1-(pentan-3-yl)cyclopropyl]acetic acid
4-Amino-4-(difluoromethyl)cyclohexan-1-ol
1,1,1-trifluoro-3-(4-methyl-1H-imidazol-5-yl)propan-2-amine
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tert-butyl N-{4-fluoro-2-[(4-hydroxypiperidin-4-yl)methyl]phenyl}carbamate

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