2,2'-Azobis(2-methylpropionitrile)

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Names

[ CAS No. ]:
78-67-1

[ Name ]:
2,2'-Azobis(2-methylpropionitrile)

[Synonym ]:
2,2′-azobis(isobutyronitrile)
2,2-azobis(isobutyronitrile)
2,2'-[(E)-1,2-Diazenediyl]bis(2-methylpropanenitrile)
azobis(isobutyronitrile)
Propanenitrile, 2,2'-azobis[2-methyl-
2,2'-azobis-(2-methylpropionitrile)
2,2'-Azo-bis(isobutyronitrile)
Azodiisobutyrodinitrile
2,2'-Azobis(isobutyronitrile)
a,a'-azobis(isobutyronitrile)
azobisisobutyronitrile
EINECS 201-132-3
2,2'-Azobis[2-methylpropanenitrile]
KE-P 13
KB-P 13
Porofor-57
MFCD00013808
2,2'-azo-bis-isobutyronitrile
a,a'-azobisisobutyronitrile
azodiisobutyronitrile
azobisisobutironitrile
2,2'-azobis(isobutylonitrile)
VAZO 64
2,2'-Azodiisobutyronitrile
2,2'-Azobisisobutyronitrile
Propionitrile, 2,2'-azobis[2-methyl-
Vazo
2,2'-(E)-Diazene-1,2-diylbis(2-methylpropanenitrile)
AIBN
2,2′-azobis(2-methylpropionitrile)
2,2'-azo-bisisobutyronitrile
2,2′-azobisisobutyronitrile
2,2'-Azobis(2-methylpropionitrile)
a,a'-Azodiisobutyronitrile
Propanenitrile, 2,2'-[(E)-1,2-diazenediyl]bis[2-methyl-
Azo-bis-isobutyronitrile
α,α′-azobisisobutyronitrile
AIBN-64
2,2'-azobis-2-methylpropanenitrile

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
236.2±25.0 °C at 760 mmHg

[ Melting Point ]:
102-104 °C (dec.)(lit.)

[ Molecular Formula ]:
C₈H₁₂N₄

[ Molecular Weight ]:
164.208

[ Flash Point ]:
96.6±23.2 °C

[ Exact Mass ]:
164.106201

[ PSA ]:
72.30000

[ LogP ]:
1.26

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.491

[ Stability ]:
Stability Flammable solid. Shock sensitive. Thermally unstable. May be explosive in combination with acetone or heptane. Incompatible with oxidizing agents.

[ Water Solubility ]:
Insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UG0800000

CHEMICAL NAME :: Propionitrile, 2,2'-azobis(2-methyl-

CAS REGISTRY NUMBER :: 78-67-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C8-H12-N4

MOLECULAR WEIGHT :: 164.24

WISWESSER LINE NOTATION :: NCX1&1&NUNX1&1&CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555369

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >12 gm/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - excitement Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555369

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555369

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 16,367,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,146,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 16,367,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 16,367,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 16,367,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2200 mg/kg/11D-C

TOXIC EFFECTS :: Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555369 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84048 No. of Facilities: 63 (estimated) No. of Industries: 4 No. of Occupations: 7 No. of Employees: 640 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84048 No. of Facilities: 89 (estimated) No. of Industries: 7 No. of Occupations: 21 No. of Employees: 4313 (estimated) No. of Female Employees: 116 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H304-H315-H336-H361d-H373

[ Supplemental HS ]:
Repeated exposure may cause skin dryness or cracking.

[ Precautionary Statements ]:
P210-P261-P281-P301 + P310-P331

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
E;Xn

[ Risk Phrases ]:
R2;R11;R20/22;R52/53

[ Safety Phrases ]:
S39-S41-S47-S61

[ RIDADR ]:
UN 3234 4.1

[ WGK Germany ]:
2

[ RTECS ]:
UG0800000

[ Packaging Group ]:
II

[ Hazard Class ]:
4.1

[ HS Code ]:
2927000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Amino-2-methylpropanenitrile
Propionitrile, 2,2-hydrazobis(2-methyl- (8CI)
N-Hexadecyltrimethylammonium chloride
Diazene,1,2-bis(1-chloro-1-methylethyl)-
Sodium cyanide
benzene
Benzoyl peroxide

DownStream

2-methyl-2-(2-methylprop-1-enylideneamino)propanenitrile
Tetramethylsuccinonitrile
Isobutyronitrile
N-(1-Cyano-1-methylethyl)isobutyramide
4-(Methylsulfonyl)benzylchloride
3-chloropropiononitrile
Chloropivaloyl chloride
3-Nitrobenzyl bromide
5,5-Diethoxy-2-pentanone
Disulfone,bis(4-methylphenyl) (9CI)

Customs

[ HS Code ]: 2927000090

[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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