2,3-Dichloropropene

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Names

[ CAS No. ]:
78-88-6

[ Name ]:
2,3-Dichloropropene

[Synonym ]:
MFCD00000943
2,3-dichloroprop-1-ene
EINECS 201-153-8

Chemical & Physical Properties

[ Density]:
1.204 g/mL at 25 °C(lit.)

[ Boiling Point ]:
94 °C(lit.)

[ Melting Point ]:
10°C

[ Molecular Formula ]:
C3H4Cl2

[ Molecular Weight ]:
110.97000

[ Flash Point ]:
50 °F

[ Exact Mass ]:
109.96900

[ LogP ]:
1.97770

[ Vapour density ]:
3.8 (vs air)

[ Vapour Pressure ]:
44 mm Hg ( 20 °C)

[ Index of Refraction ]:
n20/D 1.461(lit.)

[ Water Solubility ]:
<0.1 g/100 mL at 22 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UC8400000
CHEMICAL NAME :
Propene, 2,3-dichloro-
CAS REGISTRY NUMBER :
78-88-6
BEILSTEIN REFERENCE NO. :
1361491
LAST UPDATED :
199806
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C3-H4-Cl2
MOLECULAR WEIGHT :
110.97
WISWESSER LINE NOTATION :
G1YGU1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3100 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1580 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
300 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5383 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 302 (estimated) No. of Female Employees: 3 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H312-H315-H318-H332-H335-H341-H412

[ Precautionary Statements ]:
P210-P261-P273-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R20/21/22;R37/38;R40;R41;R52/53

[ Safety Phrases ]:
S9-S16-S23-S26-S36/37/39-S61

[ RIDADR ]:
UN 2047 3/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
UC8400000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
29032900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,2,3-Trichloropropane
  • 2-chloropropene
  • propene
  • 3-Chloropropyne
  • 1,3-Dichloropropane
  • 3-Chloro-1-propanol
  • 1,1-dichlorocyclopropane
  • Carbon tetrachloride
  • 2-methoxyethanol
  • 1-bromo-2,3-dichloropropane

DownStream

  • 1,3-Dichloroacetone
  • 2-chloro-3-isothiocyanato-prop-1-ene
  • 2-(2-chloroprop-2-enoxy)isoindole-1,3-dione
  • 1-chloro-2,2-difluoropropane
  • 1,2-dichloro-2-fluoropropane
  • 1,2,2-trichloropropane
  • 2-CHLOROALLYL MERCAPTAN
  • 2-chloroprop-2-enyl(trimethyl)silane
  • 3-chlorobut-3-enenitrile
  • Pent-2-yne

Customs

[ HS Code ]: 29032900

Articles

Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity.

Bioorg. Med. Chem. 16 , 5720-32, (2008)

The risk of the presence of haloacetic acids in drinking water as chlorination by-products and the shortage of experimental mutagenicity data for most of them requires a research work. This paper desc...

Mutagenicity of chloroolefins in the Salmonella/mammalian microsome test. III. Metabolic activation of the allylic chloropropenes allyl chloride, 1,3-dichloropropene, 2,3-dichloro-1-propene, 1,2,3-trichloropropene, 1,1,2,3-tetrachloro-2-propene and hexachloropropene by S9 mix via two different metabolic pathways.

Mutat. Res. 170(1-2) , 1-9, (1986)

In the presence of S9 mix all allylic chloropropenes tested exert considerable indirect mutagenic activity which is most pronounced for 1,2,3-trichloropropene. Lower as well as higher chlorinated deri...

Evidence for a radical mechanism of the dechlorination of chlorinated propenes mediated by the tetrachloroethene reductive dehalogenase of Sulfurospirillum muftivorans.

Environ. Sci. Technol. 41(21) , 7370-5, (2007)

The reductive dehalogenation of chlorinated propenes was studied with the tetrachloroethene reductive dehalogenase purified from Sulfurospirillum multivorans to obtain indications for a radical mechan...


More Articles

Related Compounds

  • 2-[[3-(1-benzofuran-2-yl)-3,4-dihydro-2H-pyrrol-5-yl]amino]ethanol
  • 2,3,6-Trichloropyridine
  • 2-(3-Chloroprop-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 2,3-Dichlorobenzoyl
  • 2,3-Dichlorodibenzo-p-dioxin
  • 2,3,6-Tribromo-5-methylpyridine
  • 3-Methyl-2-phenyl-4(3H)-pyrimidinone
  • 1-(5-Bromopyridin-3-yl)cyclopropane-1-carbaldehyde
  • 3-Bromo-5-(1-ethenylcyclopropyl)pyridine
  • Ethyl 3-(ethoxyimino)propanoate
  • 2-(4-methyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)ethan-1-amine
  • 1-Ethynyl-3-methoxy-2-methylbenzene
  • 5-Amino-7-chloro-3-methyl-2(3H)-benzoxazolone
  • 6,7-difluoro-2-methyl-3,4-dihydro-2H-1,4-benzoxazin-3-one
  • Cyclohexaneacetamide, N-(2-bromoethyl)-N-(1-methylethyl)-
  • 4-[2-(5-Methyl-1,3,4-oxadiazol-2-yl)ethyl]aniline
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