Methylglyoxal

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Names

[ CAS No. ]:
78-98-8

[ Name ]:
Methylglyoxal

[Synonym ]:
2-oxo-propanal
2-oxo-Propionaldehyde
methyl-glyoxal
α-Ketopropionaldehyde
acetylformaldehyde
2-keto Propionaldehyde
Pyruvaldehyde (8CI)
Ketopropionaldehyde
2-Oxopropanal
MFCD00006960
Methylglyoxal
Pyruvic aldehyde
Propanal, 2-oxo-
pyruvaldehyde
EINECS 201-164-8

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
72.0±0.0 °C at 760 mmHg

[ Melting Point ]:
25 °C

[ Molecular Formula ]:
C₃H₄O₂

[ Molecular Weight ]:
72.063

[ Flash Point ]:
2.5±4.4 °C

[ Exact Mass ]:
72.021126

[ PSA ]:
34.14000

[ LogP ]:
-0.80

[ Vapour Pressure ]:
120.9±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.364

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
>=10 g/100 mL at 17 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UZ0700000

CHEMICAL NAME :: Pyruvaldehyde

CAS REGISTRY NUMBER :: 78-98-8

BEILSTEIN REFERENCE NO. :: 0906750

LAST UPDATED :: 199701

DATA ITEMS CITED :: 31

MOLECULAR FORMULA :: C3-H4-O2

MOLECULAR WEIGHT :: 72.07

WISWESSER LINE NOTATION :: VHV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 179 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 252 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - guinea pig Cells - not otherwise specified

DOSE/DURATION :: 6600 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 38,339,1982 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 51,443,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 51,443,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 51,443,1991

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
-

[ HS Code ]:
2914400090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

acetol
DL-Glyceric aldehyde
Glycerol
Propylene Glycol
Mesitylene
2-Hydroxypropanal
Benzalacetone
L-Arabinopyranose
1,1-Dimethoxyacetone
Platinum(2+) ethanedioate-1,2-cyclohexanediamine (1:1:1)

DownStream

1-methyl-3,4-dihydro-beta-carboline-3-carboxylic acid
1H-Pyrido[3,4-b]indole-3-carboxylicacid, 2,3,4,9-tetrahydro-1-methyl-
2-Ethyl-3,5-dimethylpyrazine
5-Isobutyl-2,3-dimethylpyrazine
2,5-dimethyl-3-(E-1-propenyl)pyrazine
2-Ethyl-3,5-dimethylpyrazine
2-acetyl-5-methyl pyrazine
2-Ethyl-5-methylpyrazine
5-Ethyl-2,3-dimethylpyrazine
2,3-Dimethylpyrazine

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new three-domain family of bacterial flavoproteins.

Biochem. J. 464(3) , 387-99, (2014)

The aaoSo gene from Streptococcus oligofermentans encodes a 43 kDa flavoprotein, aminoacetone oxidase (SoAAO), which was reported to possess a low catalytic activity against several different L-amino ...

The Chilean wild raspberry (Rubus geoides Sm.) increases intracellular GSH content and protects against H2O2 and methylglyoxal-induced damage in AGS cells.

Food Chem. 194 , 908-19, (2015)

The Chilean raspberry Rubus geoides Sm. (Rosaceae) is a native species occurring in the Patagonia. Five R. geoides samples were assessed for phenolic content and composition, antioxidant activity, eff...

Novel HPLC--Fluorescence methodology for the determination of methylglyoxal and glyoxal. Application to the analysis of monovarietal wines "Ribera del Guadiana".

Food Chem. 187 , 159-65, (2015)

The determination and quantification of α-dicarbonyl compounds, glyoxal and methylglyoxal, in "Ribera del Guadiana" monovarietal wines (Extremadura, Spain) without sample clean-up has been carried out...