Hydroxylamine

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Names

[ CAS No. ]:
7803-49-8

[ Name ]:
Hydroxylamine

[Synonym ]:
MFCD00044522
Hydroxylamine
EINECS 232-259-2
hydroxyl amine
Hydroxylamine solution

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
56.5±9.0 °C at 760 mmHg

[ Melting Point ]:
7°C

[ Molecular Formula ]:
H3NO

[ Molecular Weight ]:
33.030

[ Exact Mass ]:
33.021465

[ PSA ]:
46.25000

[ LogP ]:
-0.81

[ Vapour Pressure ]:
179.1±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.395

[ Stability ]:
Stable. Incompatible with oxidizing agents, potassium dichromate, chromium trioxide, zinc, calcium, copper, sodium, ammonia, carbonyls, phosphorus halides, pyridine, hypochlorites.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NC2975000
CHEMICAL NAME :
Hydroxylamine
CAS REGISTRY NUMBER :
7803-49-8
LAST UPDATED :
199710
DATA ITEMS CITED :
49
MOLECULAR FORMULA :
H3-N-O
MOLECULAR WEIGHT :
33.04
WISWESSER LINE NOTATION :
ZQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Human Leukocyte
DOSE/DURATION :
25 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 6,375,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84783 No. of Facilities: 116 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 1722 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84783 No. of Facilities: 112 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees: 2689 (estimated) No. of Female Employees: 1481 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H290-H302-H315-H317-H318-H335-H351-H373-H400

[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R5;R22;R37/38;R41;R43;R48/22;R50

[ Safety Phrases ]:
S23-S26-S36/37/39-S47-S61-S22

[ RIDADR ]:
UN 3082 9/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
NC2975000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • nitric acid
  • Hydroxyamine hydrochloride
  • Potassium hydroxide
  • potassium t-butoxide
  • sodium butoxide
  • sodium nitrate
  • Water
  • Sodium nitrite
  • nitric oxide
  • Ammonia

DownStream

  • 2-Indanone oxime
  • glyoxime
  • Benzooxazol-2-ylamine
  • Formamide,N-(2-hydroxyphenyl)-
  • Benzophenone oxime
  • monochloroethane
  • Ethyl benzoate
  • 2-nitro-1-naphthylamine
  • Propanedioic acid,2-(hydroxyimino)-, 1,3-dimethyl ester
  • Benzenamine,2,4,6-trinitro-

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Related Compounds

  • hydroxylamine*CO
  • Tha-hydroxylamine
  • hydroxylamine-18O
  • N-Z-Hydroxylamine
  • bis(hydroxylamine)
  • O-Bn-hydroxylamine
  • 2-Chloro-6-(2-hydroxyethyl)quinoline-3-carbonitrile
  • 2-Fluoro-2,3,3-trimethylbutan-1-amine
  • (R)-methyl 2-(1-(benzyloxycarbonyl)-2-methylpyrrolidin-2-yl)-1H-indole-4-carboxylate
  • Ethyl 4-[2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
  • (R)-methyl 2-(2-methylpyrrolidin-2-yl)-1H-indole-4-carboxylate
  • Methyl 12-methoxy-5,6-dihydrobenzo[a]acridine-11-carboxylate
  • 4-(1-Fluorocyclobutyl)aniline
  • 3-(Cyclopropyldifluoromethyl)aniline
  • 5-fluoro-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one
  • 2-[3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-1-yl]ethan-1-ol
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