4,5-Difluoro-2-nitroaniline

Suppliers

Names

[ Name ]:
4,5-Difluoro-2-nitroaniline

[Synonym ]:
2-nitro-3,4-difluoroaniline
MFCD00010876
4,5-difluoro-2-nitro-aniline
2-nitro-4,5-difluoroaniline
4,5-difluoro-2-nitro-phenylamine
4,5-Difluoro-2-nitroaniline
3,4-Difluoro-6-nitroaniline
4,5-Difluoro-2-nitrobenzenamine
Benzenamine, 4,5-difluoro-2-nitro-
ZR CF DF FNW

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
308.1±37.0 °C at 760 mmHg

[ Melting Point ]:
107-108 °C(lit.)

[ Molecular Formula ]:
C₆H₄F₂N₂O₂

[ Molecular Weight ]:
174.105

[ Flash Point ]:
140.1±26.5 °C

[ Exact Mass ]:
174.024078

[ PSA ]:
71.84000

[ LogP ]:
2.10

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.575

[ Storage condition ]:
Room temperature.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2921420090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1,2,4-Trifluoro-5-nitrobenzene
Acetamide,N-(3,4-difluorophenyl)-
4,5-Difluoro-2-nitro-benzamide
ETHYL2-CHLORO-5-NITROBENZOATE
3,4-Difluoroaniline

DownStream

4-fluoro-5-morpholin-4-ylbenzene-1,2-diamine
1H-Benzimidazole,5,6-difluoro-
1,2-Diamino-4,5-difluorobenzene
4-Fluoro-5-methoxy-2-nitroaniline
5,6-Difluoro-2,1,3-benzoxadiazole 1-oxide
4-Fluoro-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine
2-(DIETHOXYMETHYL)-5,6-DIFLUORO-1H-BENZO[D]IMIDAZOLE

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Novel substituted quinoxaline 1,4-dioxides with in vitro antimycobacterial and anticandida activity.

Eur. J. Med. Chem. 37(5) , 355-66, (2002)

Thirty-six 6(7)-substituted-3-methyl- or 3-halogenomethyl-2-phenylthio-phenylsulphonyl-chloro-quinoxaline 1,4-dioxides belonging to series 3-6 were synthesised and submitted to a preliminary in vitro ...

Design, synthesis, and antiviral evaluation of 2-chloro-5,6-dihalo-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections.

J. Med. Chem. 40(5) , 811-8, (1997)

2-Chloro-5,6-difluorobenzimidazole (8) was prepared from 4,5-difluoro-2-nitroaniline (5) via successive reduction, cyclization, and diazotization reactions. 2-Chloro-5,6-dibromobenzimidazole (10) was ...

Synthesis of fluorinated derivatives of benzo [k] fluoranthene and indeno [1, 2, 3-cd] pyrene and 8, 9-dihydro-8, 9-epoxybenzo [k] fluoranthene. Rice JE, et al.

J. Org. Chem. 53(8) , 1775-79, (1988)

4,5-Difluoro-2-nitrobenzoic acid
4,5-Difluoro-2-methylbenzonitrile
4,5-difluoro-2-[2-(1H-imidazol-2-yl)phenyl]-1H-benzimidazole
4,5-difluoro-2-methoxyaniline
4,5-DIFLUORO-2(3H)-BENZOTHIAZOLONE
4,5-DIFLUORO-2-(TRIFLUOROMETHYL)BENZIMIDAZOLE
6,6-Dimethyl-2,7-dioxa-5-azaspiro[3.5]nonane
2-Methyl-1-oxa-5-azaspiro[5.7]tridecane
4-Bromo-2-cyclopropoxy-5-fluoroaniline
4,4''-Diamino-[1,1':4',1''-terphenyl]-2,2''-dicarboxylic acid
3,3-Dimethylcyclohexane-1-sulfonyl fluoride
5-(4-ethyl-1H-pyrazol-1-yl)pyridine-3-carbaldehyde
1-[5-(1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-one
5-(1-amino-3-methylbutyl)-N,N-bis(2-methylpropyl)-1,2,4-oxadiazol-3-amine
3-{[(Tert-butoxy)carbonyl]amino}-3,5,5-trimethylhexanoic acid
[2-({[(5-Chlorofuran-2-yl)methyl]sulfanyl}methyl)prop-2-en-1-yl](ethyl)amine

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