5,10-dihydro-4H-imidazo[2,1-c][1,4]benzodiazepine

Names

[ CAS No. ]:
78105-31-4

[ Name ]:
5,10-dihydro-4H-imidazo[2,1-c][1,4]benzodiazepine

[Synonym ]:
10,11-diidro-5H-imidazo<2,1-c><1,4>benzodiazepine

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
450.1ºC at 760 mmHg

[ Molecular Formula ]:
C11H11N3

[ Molecular Weight ]:
185.22500

[ Flash Point ]:
226ºC

[ Exact Mass ]:
185.09500

[ PSA ]:
29.85000

[ LogP ]:
1.99490

[ Index of Refraction ]:
1.698

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI2922300
CHEMICAL NAME :
5H-Imidazo(2,1-c)(1,4)benzodiazepine, 10,11-dihydro-
CAS REGISTRY NUMBER :
78105-31-4
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H11-N3
MOLECULAR WEIGHT :
185.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 40,429,1985

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(o-nitrobenzyl)-imidazole-2-carboxaldehyde
  • 5H-Imidazo(2,1-c)(1,4)benzodiazepina [Italian]

DownStream

  • 5H-Imidazo(2,1-c)(1,4)benzodiazepina [Italian]

Related Compounds

  • ethyl 4-oxo-5,10-dihydro-4H-benzo[e]pyrazolo[1,5-a][1,4]diazepine-2-carboxylate
  • 4-(8-Chloro-4H-imidazo[2,1-c][1,4]benzoxazin-2-yl)phenyl methyl ether
  • 7,8-dimethoxy-10H-imidazo[2,1-c][1,4]benzodiazepine
  • 7,8-dimethoxy-5,6,7,10-tetrahydro-1H-imidazo[2,1-c][1,4]benzodiazepine
  • 6H-1,3-Dioxolo(4,5-h)imidazo(2,1-c)(1,4)benzodiazepine,5,11-dihydro
  • (S)-(+)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 3,4-Dichloro-N-(2-(2-(furan-2-ylmethylene)hydrazinyl)-2-oxoethyl)benzamide
  • 2-(3,5-Dichlorophenyl)thiazole-4-carbaldehyde
  • tert-Butyl-DL-alanine