CDPPB

Names

[ CAS No. ]:
781652-57-1

[ Name ]:
CDPPB

[Synonym ]:
mGluR5 Ligand,CDPPB
CDPPB

Chemical & Physical Properties

[ Density]:
1.203g/cm3

[ Boiling Point ]:
523.277ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₁₆N₄O

[ Molecular Weight ]:
364.39900

[ Flash Point ]:
270.268ºC

[ Exact Mass ]:
364.13200

[ PSA ]:
70.71000

[ LogP ]:
4.73628

[ Index of Refraction ]:
1.655

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex.

J. Neurosci. 34(22) , 7562-74, (2014)

Addiction is a chronic relapsing disorder in which relapse is often initiated by exposure to drug-related cues. The present study examined the effects of mGluR5 activation on extinction of ethanol-cue...

The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease.

Neurobiol. Dis. 73 , 163-73, (2014)

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in the amino-terminal region of the huntingtin protein (htt), leading to motor dysfunc...

Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice.

Fundam. Clin. Pharmacol. 27(5) , 483-8, (2013)

This study was undertaken to examine the effects of CDPPB (3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide), a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGlu₅), on co...