4-(2-Isocyanoethyl)morpholine

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Names

[ CAS No. ]:
78375-48-1

[ Name ]:
4-(2-Isocyanoethyl)morpholine

[Synonym ]:
MFCD00040506
4-(2-Isocyanoethyl)morpholine
Morpholine, 4-(2-isocyanoethyl)-

Chemical & Physical Properties

[ Density]:
1.017 g/mL at 20 °C(lit.)

[ Boiling Point ]:
72-73 °C0.7 mm Hg(lit.)

[ Molecular Formula ]:
C7H12N2O

[ Molecular Weight ]:
140.183

[ Flash Point ]:
110ºC

[ Exact Mass ]:
140.094955

[ PSA ]:
12.47000

[ Index of Refraction ]:
n20/D 1.469

[ Storage condition ]:
−20°C

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H315-H319-H331-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R23/24/25;R36/37/38

[ Safety Phrases ]:
S26-S36/37-S45

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-(2-morpholino-ethyl)-formamide
  • 8-oxa-2,5-diazaspiro[4.5]dec-1-en-5-ium chloride
  • 8-oxa-2,5-diazaspiro[4.5]dec-1-en-5-ium 4-methylbenzenesulfonate

DownStream

  • 4-Phenylmorpholine
  • N-Ethylmorpholine
  • N-T-BOC-L-PROLINE-N-HYDROXYSUCCINIMIDE ESTER

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

[Syntheses of human little gastrin-I and its leucine-15, norleucine-15 and methoxinine-15 analogs].

Hoppe. Seylers. Z. Physiol. Chem. 364 , 157, (1983)

Human little gastrin-I is known to exhibit a high tendency to air-oxidation of its methionine-15 residue to the corresponding S-oxide derivative, with concomitant loss of biological activity. Since it...

Involvement of soluble scavenger receptor A in suppression of T cell activation in patients with chronic hepatitis B.

BMC Immunol. 16 , 29, (2015)

Scavenger receptor A (SRA) is expressed predominantly in phagocytic cells playing an essential role in the host immune defense against invading microorganisms. Our previous study reported the presence...

Partial virological response to entecavir treatment in nucleos(t)ide-naïve patients with HBeAg-positive chronic hepatitis B is not caused by reduced sensitivity.

Biochem. Biophys. Res. Commun. 464 , 1185-91, (2015)

Some patients with chronic hepatitis B (CHB) receiving entecavir (ETV) exhibit partial virological response (PVR) to ETV and the mechanism is not clear. In this study, we aim to investigate the in vit...


More Articles

Related Compounds

  • 4-(2-isocyanoethyl)-1-(4-methylphenyl)sulfonylimidazole
  • 4-(2-Isocyanoethyl)pyridine
  • 4-(2-isocyanoethyl)-2-methoxy-1-prop-2-ynoxybenzene
  • 4-[2-(Morpholine-4-carbonyl)-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester
  • (R)-1-(4-(2-(morpholine-4-carbonyl)pyrrolidin-1-yl)phenyl)propan-1-one
  • 1-benzyl-4-(2-isocyanoethyl)imidazole