FG 7142

Suppliers

Names

[ CAS No. ]:
78538-74-6

[ Name ]:
FG 7142

[Synonym ]:
B-carboline-3-carboxylic acid N-*methylamide
FG 7142

Chemical & Physical Properties

[ Density]:
1.328g/cm3

[ Boiling Point ]:
576.3ºC at 760 mmHg

[ Molecular Formula ]:
C13H11N3O

[ Molecular Weight ]:
225.24600

[ Flash Point ]:
302.3ºC

[ Exact Mass ]:
225.09000

[ PSA ]:
57.78000

[ LogP ]:
2.46660

[ Index of Refraction ]:
1.735

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU9780100
CHEMICAL NAME :
9H-Pyrido(3,4-b)indole-3-carboxamide, N-methyl-
CAS REGISTRY NUMBER :
78538-74-6
LAST UPDATED :
199212
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H11-N3-O
MOLECULAR WEIGHT :
225.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
150 mg/kg
SEX/DURATION :
female 12-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 22,53,1991

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UU9780100

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • B-CARBOLINE-3-CARBOXYLIC ACID METHYLESTE R
  • methylamine
  • L(-)-Tryptophan
  • Lycoperodine 1
  • 2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE-3-CARBOXYLICACIDMETHYLESTER
  • Methylamine hydrochloride
  • (1S,3S)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
  • TNCA
  • D-(+)-Glucose
  • ETHYL BETA-CARBOLINE-3-CARBOXYLATE

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Performance in anxiety and spatial memory tests following bilateral vestibular loss in the rat and effects of anxiolytic and anxiogenic drugs.

Behav. Brain Res. 235(1) , 21-9, (2012)

Vestibular dysfunction in humans is associated with anxiety and cognitive disorders. However, various animal studies of the effects of vestibular loss have yielded conflicting results, from reduced an...

Hypothalamic orexin's role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause model.

Psychoneuroendocrinology 65 , 127-37, (2016)

Distressing symptoms such as hot flashes and sleep disturbances affect over 70% of women approaching menopause for an average of 4-7 years, and recent large cohort studies have shown that anxiety and ...

The influence of NMDA and GABA(A) receptors and glutamic acid decarboxylase (GAD) activity on attention.

Psychopharmacology 225(1) , 31-9, (2013)

Attention dysfunction is the hallmark of cognitive deficits associated with major psychiatric illnesses including schizophrenia. Cognitive deficits of schizophrenia have been attributed to reduced fun...


More Articles

Related Compounds

  • FG-4592
  • FG-4592 intermediate 3
  • FG 488 DHPE
  • FG-3019
  • FG-944
  • FG-2216
  • 1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pent-4-ynoyl]-octahydrocyclopenta[b]pyrrole-3a-carboxylic acid
  • 1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutanecarbonyl]-octahydrocyclopenta[b]pyrrole-3a-carboxylic acid
  • 1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoyl]-octahydrocyclopenta[b]pyrrole-3a-carboxylic acid
  • 1-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoyl]-octahydrocyclopenta[b]pyrrole-3a-carboxylic acid
  • 3-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4,4,4-trifluorobutanamido]butanoic acid
  • 2-{2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1H-pyrazol-1-yl]acetamido}-2-methylbutanoic acid
  • 2-[({1-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cycloheptyl}formamido)oxy]propanoic acid
  • 2-({4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-5-methylhexanamido}oxy)propanoic acid
  • 2-{[(2S,3R)-3-(tert-butoxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]oxy}propanoic acid
  • (2S)-2-{[1-benzyl-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-4-yl]formamido}-4-hydroxybutanoic acid