Bonnecor

Names

[ CAS No. ]:
78816-67-8

[ Name ]:
Bonnecor

[Synonym ]:
Ethyl (5-((dimethylamino)acetyl)-10,11-dihydro-5H-dibenz(B,F)azepin-3-yl)carbamate monohydrochloride
Carbamic acid,(5-((dimethylamino)acetyl)-10,11-dihydro-5H-dibenz(B,F)azepin-3-yl)-,ethyl ester,monohydrochloride
TIRACIZINEHYDROCHLORIDE
AWD-19-166
Tiracizine Hydrochioride
3-Carbethoxyamino-5-dimethylaminoacetyl-10,11-dihydrodibenz(B,F)azepine hydrochloride
GS-015
5H-Dibenz(B,F)azepine-3-carbamic acid,10,11-dihydro-5-((dimethylamino)acetyl)-,ethyl ester,monohydrochloride
3-Carbethoxyamino-5-dimethylaminoacetyl-iminodibenzyle-Hydrochlorid

Chemical & Physical Properties

[ Boiling Point ]:
525.3ºC at 760 mmHg

[ Molecular Formula ]:
C21H26ClN3O3

[ Molecular Weight ]:
403.90200

[ Flash Point ]:
271.5ºC

[ Exact Mass ]:
403.16600

[ PSA ]:
61.88000

[ LogP ]:
4.51990

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HN8110000
CHEMICAL NAME :
5H-Dibenz(b,f)azepine-3-carbamic acid, 10,11-dihydro-5-((dimethylamino)acetyl)-, ethyl ester, monohydrochloride
CAS REGISTRY NUMBER :
78816-67-8
LAST UPDATED :
199803
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C21-H25-N3-O3.Cl-H
MOLECULAR WEIGHT :
403.95

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
78 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 40,871,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10900 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 40,871,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
48 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 40,871,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5400 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 40,871,1985

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • carbamic acid
  • 10,11-Dihydro-5H-dibenzo[b,f]azepin-3-amine

DownStream

Related Compounds

  • Bonnecor-Base
  • 2-(benzo[d]isoxazol-3-yl)-N-(3-(2-phenylthiazol-4-yl)phenyl)acetamide
  • N-(3-(2-phenylthiazol-4-yl)phenyl)-4-propyl-1,2,3-thiadiazole-5-carboxamide
  • Methyl 3-({[2-(trifluoromethyl)phenyl]carbamoyl}amino)adamantane-1-carboxylate
  • 1-(2-Methylbenzo[d]thiazol-6-yl)-3-(2-(trifluoromethyl)phenyl)urea
  • 1-(6-Methoxyquinolin-8-yl)-3-(thiophen-2-ylmethyl)urea
  • 1-(6-Methoxyquinolin-8-yl)-3-[2-(trifluoromethyl)phenyl]urea
  • 1-(4-Fluorobenzyl)-3-(6-methoxyquinolin-8-yl)urea
  • 1-Isopropyl-3-(6-methoxyquinolin-8-yl)urea
  • N-(4-fluorobenzyl)-4-(2,2,2-trifluoroethyl)piperazine-1-carboxamide
  • N-(5-chloro-2-methoxyphenyl)-4-(2,2,2-trifluoroethyl)piperazine-1-carboxamide
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