methyl (3aR,4R,7aR)-2-methyl-4-(1S,2R,3-triacetoxypropyl)-3a,7a-dihydro-4H-pyrano[3,4-d]oxazole-6-carboxylate

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Names

[ CAS No. ]:
78850-37-0

[ Name ]:
methyl (3aR,4R,7aR)-2-methyl-4-(1S,2R,3-triacetoxypropyl)-3a,7a-dihydro-4H-pyrano[3,4-d]oxazole-6-carboxylate

[Synonym ]:
methyl 7,8,9-tri-O-acetyl-2,3-didehydro-2,3,5-trideoxy-4',5'-dihydro-2'-methyloxazolo<5.4-d>-D-glycero-D-talo-2-nonulopyranosidonate

Chemical & Physical Properties

[ Density]:
1.408g/cm3

[ Boiling Point ]:
469.532ºC at 760 mmHg

[ Molecular Formula ]:
C18H23NO10

[ Molecular Weight ]:
413.37600

[ Flash Point ]:
170.889ºC

[ Exact Mass ]:
413.13200

[ PSA ]:
136.02000

[ Index of Refraction ]:
1.555

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
41

[ Safety Phrases ]:
26-39

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Neu5Ac methyl ester
  • Methyl5-acetamido-4,7,8,9-tetra-O-acetyl-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonate
  • Acetonitrile
  • 2-O-Methyl-β-D-N-acetylneuraminic Acid, Methyl Ester
  • Ethanoic anhydride
  • methyl 4,7,8,9-tetra-O-acetyl-5-acetamido-2,6-anhydro-2,3,5-trideoxy-D-glycero-D-talo-non-2-enoate
  • (1S,2R)-1-((2R,3R,4S,6S)-3-acetamido-4-acetoxy-6-methoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate

DownStream

  • Zanamivir
  • 4-a-AMino-N-acetyl-2-deoxy-2,3-didehydro-D-neuraMinate
  • Methyl 5-acetamido-7,8,9-O-triacetyl-2,6-anhydro-4-azido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonate
  • Zanamivir