Fosfomycin tromethamine

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Names

[ CAS No. ]:
78964-85-9

[ Name ]:
Fosfomycin tromethamine

[Synonym ]:
mono(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate
acide [(2R,3S)-3-méthyloxiran-2-yl]phosphonique - 2-amino-2-(hydroxyméthyl)propane-1,3-diol (1:1)
[(2R,3S)-3-Methyloxiran-2-yl]phosphonsäure--2-amino-2-(hydroxymethyl)propan-1,3-diol(1:1)
methyl)-1,3-propanediol(1:1)
(2R-cis)-(3-Methyloxiranyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)propane-1,3-diol (1:1)
Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
fosfomycintrometamolsalt
FosfoMycin troMethaMine API
[(2R,3S)-3-Methyl-2-oxiranyl]phosphonic acid - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
Tromethamine fosfosmycin
tromethamine-fosfomycin
(1R,2S)-(1,2-Epoxypropyl)phosphonic Acid Compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
FOSFOMYCIN TROMETHAMOL
monuril
z1282
FOSFOMYCIN TROMETAMOL
[(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid - 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)
1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium hydrogen [(2R,3S)-3-methyloxiran-2-yl]phosphonate

Chemical & Physical Properties

[ Boiling Point ]:
357ºC at 760 mmHg

[ Molecular Formula ]:
C7H18NO7P

[ Molecular Weight ]:
259.194

[ Flash Point ]:
169.7ºC

[ Exact Mass ]:
259.082092

[ PSA ]:
166.58000

[ Water Solubility ]:
Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ9570000
CAS REGISTRY NUMBER :
78964-85-9
LAST UPDATED :
199403
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C4-H11-N-O3.C3-H7-O4-P
MOLECULAR WEIGHT :
259.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,77,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,77,1988

Safety Information

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-amino-2-(hydroxymethyl)propane-1,3-diol,oxalic acid
  • Disodium phosphonomycin

DownStream

Related Compounds

  • fosfomycin sodim
  • Fosfomycin
  • Fosfomycin calcium
  • FOSFOMYCIN CALCIUM SALT
  • fosfomycin calcium
  • fosfomycin sodim
  • 7-(Azepan-1-yl)-6-fluoro-N'-hydroxy-1-methyl-4-oxoquinoline-3-carboximidamide
  • N'-Hydroxy-1-methyl-7-morpholin-4-yl-4-oxoquinoline-3-carboximidamide
  • 7-(Azepan-1-yl)-1-ethyl-6-fluoro-N'-hydroxy-4-oxoquinoline-3-carboximidamide
  • 1-{[4-(2-methylphenyl)-4H-1,2,4-triazol-3-yl]methyl}piperidine-3-carboxylic acid
  • 2-(5-chloro-1H-indol-2-yl)acetaldehyde
  • 1-[2-(4-bromophenyl)-2-oxoethyl]-1H-1,2,3-triazole-4-carboxylic acid
  • 4-(5-Amino-4-chloro-1H-pyrazol-1-yl)phenol
  • 2-(3-aminopyrrolidin-1-yl)-N-butyl-N-ethylacetamide
  • 2-azido-N-butyl-N-ethylacetamide
  • 4-(Azidoacetyl)-6-methyl-3,4-dihydro-2H-1,4-benzoxazine
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