Thiosemicarbazide

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
208.6±23.0 °C at 760 mmHg

[ Melting Point ]:
180-183 °C (dec.)(lit.)

[ Molecular Formula ]:
CH₅N₃S

[ Molecular Weight ]:
91.14

[ Flash Point ]:
80.0±22.6 °C

[ Exact Mass ]:
91.020416

[ PSA ]:
96.16000

[ LogP ]:
-1.15

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.667

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
soluble

Click to get detail MSDS

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT4200000

CHEMICAL NAME :: Semicarbazide, thio-

CAS REGISTRY NUMBER :: 79-19-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 22

MOLECULAR FORMULA :: C-H5-N3-S

MOLECULAR WEIGHT :: 91.15

WISWESSER LINE NOTATION :: ZMYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9160 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16407 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Endocrine - hyperglycemia

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Ocular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 9100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1024 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2048 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 20 umol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,821,1976 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,111,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 72890 No. of Facilities: 435 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 4353 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 72890 No. of Facilities: 347 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1341 (estimated) No. of Female Employees: 1152 (estimated)

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300

[ Precautionary Statements ]:
P264-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R28;R52/53

[ Safety Phrases ]:
S22-S26-S36/37-S45-S61-S28A

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
VT4200000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2942000000

Click to get detail synthetic route

Precursor

2-Methyl-3-thiosemicarbazide
2,4-Dichlorobenzaldehyde
2-(1-(4-((4-acetylphenyl)thio)phenyl)ethylidene)hydrazine-1-carbothioamide
isothiocyanic acid
2-carbamothioylsulfanylacetic acid
1-(4-((4-(1-((4-methylthiazol-2(5H)-ylidene)hydrazono)ethyl)phenyl)thio)phenyl)ethan-1-one
2-(1-(4-((4-(1-((4-methylthiazol-2(5H)-ylidene)hydrazono)ethyl)phenyl)thio)phenyl)ethylidene)hydrazine-1-carbothioamide
2-(1-(4-((4-(1-((4-oxothiazolidin-2-ylidene)hydrazono)ethyl)phenyl)thio)phenyl)ethylidene)hydrazine-1-carbothioamide
Potassium thiocyanate

DownStream

Propanoic acid,2-[2-(aminothioxomethyl)hydrazinylidene]-, ethyl ester
Hydrazinecarbothioamide,2,2'-(1,2-ethanediylidene)bis-
(1-phenylpropylideneamino)thiourea
Butanoic acid,3-[2-(aminothioxomethyl)hydrazinylidene]-, ethyl ester
2,5-diphenyl-1H-pyrazolo[1,5-c]pyrimidine-7-thione
[(2-chloroquinolin-3-yl)methylideneamino]thiourea
2-(1H-pyrazol-3-yl)phenol
2-Mercaptobenzimidazole
1H-1,2,4-Triazole-3-thiol
4H-1,2,4-Triazole-3,4,5-triamine

[ HS Code ]: 2930909059

[ Summary ]:
HS:2930909059 hydrazinecarbothioamide VAT:17.0% Tax rebate rate:9.0% Supervision conditions:S MFN tariff:6.5% General tariff:30.0%

Carbamylation of immunoglobulin abrogates activation of the classical complement pathway.

Eur. J. Immunol. 44(11) , 3403-12, (2014)

Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily u...

Rhenium mixed-ligand complexes with S,N,S-tridentate thiosemicarbazone/thiosemicarbazide ligands.

Dalton Trans. 42(14) , 5111-21, (2013)

Rhenium(V) complexes containing tridentate thiosemicarbazones/thiosemicarbazides (H2L1) derived from N-[N′,N′-dialkylamino(thiocarbonyl)]benzimidoyl chlorides with 4,4-dialkylthiosemicarbazides have b...

Synthesis and antityrosinase mechanism of benzaldehyde thiosemicarbazones: novel tyrosinase inhibitors.

J. Agric. Food Chem. 60(6) , 1542-7, (2012)

p-Hydroxybenzaldehyde thiosemicarbazone (HBT) and p-methoxybenzaldehyde thiosemicarbazone (MBT) were synthesized and established by (1)H NMR and mass spectra. Both compounds were evaluated for their i...

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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Synthetic Route

Click to get detail synthetic route

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