Methyl acetate

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Names

[ CAS No. ]:
79-20-9

[ Name ]:
Methyl acetate

[Synonym ]:
methyl ortho-acetate
1-yl-acetic acid,methyl ester
acetic acid trimethyl ester
Methyl ethanoate
Devoton
Methyl acetic ester
MFCD00008711
EINECS 201-185-2
Tereton
Methylacetat
Acetic acid,methyl ester
Methylacetaat
Methyl acetate

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
44.0±3.0 °C at 760 mmHg

[ Melting Point ]:
-98 °C

[ Molecular Formula ]:
C3H6O2

[ Molecular Weight ]:
74.078

[ Flash Point ]:
-9.4±0.0 °C

[ Exact Mass ]:
74.036781

[ PSA ]:
26.30000

[ LogP ]:
0.18

[ Vapour density ]:
2.55 (vs air)

[ Vapour Pressure ]:
368.4±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.354

[ Storage condition ]:
Flammables area

[ Stability ]:
Stable. Extremely flammable - readily forms explosive mixtures with air. Note low flash point and wide explosion limits. Incompatible with strong oxidizing agents, strong bases, strong acids, nitrates. May be moisture sensitive.

[ Water Solubility ]:
250 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AI9100000
CHEMICAL NAME :
Acetic acid, methyl ester
CAS REGISTRY NUMBER :
79-20-9
LAST UPDATED :
199712
DATA ITEMS CITED :
49
MOLECULAR FORMULA :
C3-H6-O2
MOLECULAR WEIGHT :
74.09
WISWESSER LINE NOTATION :
1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
15000 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - cough Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
32000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
34 gm/m3/4H
TOXIC EFFECTS :
Behavioral - general anesthetic
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
67 gm/m3/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3705 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraduodenal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
214 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,339,1985 *** REVIEWS *** ACGIH TLV-STEL 757 mg/m3 (250 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 606 mg/m3 (200 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,28,1960 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 200 ppm (610 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,153,1971 OSHA PEL (Gen Indu):8H TWA 200 ppm (610 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (610 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (610 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (610 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993 OEL-BELGIUM:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993 OEL-DENMARK:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-FINLAND:TWA 200 ppm (610 mg/m3);STEL 250 ppm (765 mg/m3) JAN 1993 OEL-FRANCE:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993 OEL-GERMANY:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-HUNGARY:TWA 200 mg/m3;STEL 500 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:TWA 200 ppm;STEL 100 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 200 ppm (610 mg/m3);STEL 400 ppm JAN 1993 OEL-TURKEY:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 200 ppm (610 mg/m3);STEL 250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL ACETATE-air:10H TWA 200 ppm;STEL 250 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 46410 No. of Facilities: 1604 (estimated) No. of Industries: 26 No. of Occupations: 22 No. of Employees: 5611 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 46410 No. of Facilities: 387 (estimated) No. of Industries: 15 No. of Occupations: 31 No. of Employees: 20455 (estimated) No. of Female Employees: 6018 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319-H336

[ Supplemental HS ]:
Repeated exposure may cause skin dryness or cracking.

[ Precautionary Statements ]:
P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R36;R66;R67

[ Safety Phrases ]:
S16-S26-S29-S33

[ RIDADR ]:
UN 1231 3/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
AI9100000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methanol
  • carbon monoxide
  • Ethanoic anhydride
  • (acetoxymethyl)dimethoxy(methyl)silane
  • methyl iodide
  • P-NITROPHENYLACETATE
  • phenyl acetate
  • P-cresyl acetate
  • acetic acid

DownStream

  • 2-Methyl-2-imidazoline
  • 1H-IMidazole, 1-ethyl-2-Methyl
  • 1,2-Dimethylimidazole
  • acetyl iodide
  • Trimethylsilyl acetate
  • Benzyl acetylacetate
  • 2-Tridecanone
  • ether

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Related Compounds

  • methyl acetate
  • methyl acetate-d3
  • methyl acetate-d6
  • Methyl acetate-PEG1
  • 4-pyridylmethyl acetate
  • 2-thienylmethyl acetate