1,1,2,2-Tetrachloroethane

Suppliers

Names

[ CAS No. ]:
79-34-5

[ Name ]:
1,1,2,2-Tetrachloroethane

[Synonym ]:
Westron
1,1,2,2-tetrachlorethan
MFCD00000848
Tetrachlorethane
1,1,2,2-Tetrachloroethane
s-Tetrachloroethane
Bonoform
Ethane,1,1,2,2-tetrachloro
tetrachloroethane
perchloroethylen
Cellon
sym-tetrachloroethane
acetylene tetrachloride
EINECS 201-197-8

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
142.0±8.0 °C at 760 mmHg

[ Melting Point ]:
-43 °C

[ Molecular Formula ]:
C2H2Cl4

[ Molecular Weight ]:
167.849

[ Flash Point ]:
42.6±15.8 °C

[ Exact Mass ]:
165.891068

[ LogP ]:
2.17

[ Vapour density ]:
5.8 (vs air)

[ Vapour Pressure ]:
7.1±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.480

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases. Reacts violently with sodium, potassium, nitrates, 2,4-dinitrophenyl disulphide.

[ Water Solubility ]:
0.3 g/100 mL (25 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KI8575000
CHEMICAL NAME :
Ethane, 1,1,2,2-tetrachloro-
CAS REGISTRY NUMBER :
79-34-5
BEILSTEIN REFERENCE NO. :
0969206
LAST UPDATED :
199712
DATA ITEMS CITED :
70
MOLECULAR FORMULA :
C2-H2-Cl4
MOLECULAR WEIGHT :
167.84
WISWESSER LINE NOTATION :
GYGYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
1000 mg/m3/30M
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4500 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
821 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1108 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - ataxia
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Behavioral - sleep Liver - fatty liver degeneration
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
19 gm/m3/45M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - general anesthetic Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Liver - fatty liver degeneration
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9480 mg/kg/6W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/m3/4H/6W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 gm/kg/40D-I
TOXIC EFFECTS :
Behavioral - sleep Liver - fatty liver degeneration Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
42 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
55 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
110 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 6.9 mg/m3 (1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,477,1979 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,354,1987 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,354,1987 TOXICOLOGY REVIEW AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 40(3),A46,1979 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (35 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,249,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (35 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (35 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (35 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (35 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (7 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 1 ppm (7 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 1 ppm (6.9 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 1 ppm (7 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 1 ppm (7 mg/m3);STEL 3 ppm (21 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 1 ppm (7 mg/m3);STEL 5 ppm (35 mg/m3) JAN 1993 OEL-GERMANY:TWA 1 ppm (7 mg/m3);Skin;Carcinogen JAN 1993 OEL-JAPAN:TWA 1 ppm (6.9 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (7 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (35 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:TWA 1 ppm JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (7 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 5 ppm (35 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,1,2,2-TETRACHLOROETHANE-air:10H CA TWA 1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 71460 No. of Facilities: 244 (estimated) No. of Industries: 8 No. of Occupations: 15 No. of Employees: 7044 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 71460 No. of Facilities: 501 (estimated) No. of Industries: 2 No. of Occupations: 10 No. of Employees: 4145 (estimated) No. of Female Employees: 926 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H331-H310-H370-H412

[ Precautionary Statements ]:
P210-P260-P273-P280-P301 + P310-P302 + P350

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;

[ Risk Phrases ]:
R26/27;R51/53

[ Safety Phrases ]:
S38-S45-S61-S36/37

[ RIDADR ]:
UN 1702 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
KI8575000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (E)-1,2-Dichloroethene
  • Acetylene
  • 4-(chlorotris(2,2,2-trichloroethoxy)-l5-phosphanyl)morpholine
  • (Z)-1,2-Dichloroethene
  • Ethane,1,1,1,2,2-pentachloro-
  • dichloromethane
  • dichloroethane
  • Dichloramine B

DownStream

  • 1,3-INDANDIONE
  • 2-ACETYL-1,3-INDANEDIONE
  • f 133a
  • 1,1-dichloro-2,2-difluoroethane
  • 1,1-Dichloro-2,2,2-trifluoroethane
  • 1,2,2-Trichloro-1,1-difluoroethane
  • 1,2-dichloro-1,2-difluoroethane
  • 1,1,2-trichloro-2-fluoroethane
  • 1,1,1-Trichloro-Trifluoroethane
  • 1,1,2-trichloro-1-fluoroethane

Articles

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.

Eur. J. Med. Chem. 44 , 3658-64, (2009)

A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...

Simultaneous derivatization and solid-based disperser liquid-liquid microextraction for extraction and preconcentration of some antidepressants and an antiarrhythmic agent in urine and plasma samples followed by GC-FID.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 55-61, (2015)

The present work is based on a one-step method including derivatization and solid-based disperser liquid-liquid microextraction followed by gas chromatography-flame ionization detection (GC-FID) for t...


More Articles

Related Compounds

  • 1,1,2,2-tetrachloroethane-d2
  • 1,1,2,2-Tetrachloroethane-13C2
  • 2-fluoro-1,1,2,2-tetrachloroethane
  • 1,2-Dibromo-1,1,2,2-tetrachloroethane
  • 1,2-Diethoxy-1,1,2,2-tetrachloroethane
  • 1,2-Diethoxy-1,1,2,2-tetrachloroethane
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 3-(2-Ethylphenyl)-3-hydroxypropanenitrile
  • 1-(4-Amino-3-ethylpiperidin-1-yl)propan-1-one
  • tert-Butyl-DL-alanine